Impact of Tumor Site and Adjuvant Radiotherapy on Survival of Patients with Adenoid Cystic Carcinoma: A SEER Database Analysis
Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor, displaying aggressive behavior with frequent recurrence and metastasis. Little information exists regarding the impact of clinicopathological parameters and adjuvant radiotherapy (aRT) on ACC disease specific (DSS) and overall survival (...
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doaj-6d5281d63d0040a8a2cb94fcb466b8542021-02-04T00:01:22ZengMDPI AGCancers2072-66942021-02-011358958910.3390/cancers13040589Impact of Tumor Site and Adjuvant Radiotherapy on Survival of Patients with Adenoid Cystic Carcinoma: A SEER Database AnalysisJason Tasoulas0Kimon Divaris1Stamatios Theocharis2Douglas Farquhar3Colette Shen4Trevor Hackman5Antonio L. Amelio6First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USAFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Otolaryngology/Head and Neck Surgery, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Otolaryngology/Head and Neck Surgery, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, 385 South Columbia Street, Chapel Hill, NC 27599-7455, USAAdenoid cystic carcinoma (ACC) is a rare salivary gland tumor, displaying aggressive behavior with frequent recurrence and metastasis. Little information exists regarding the impact of clinicopathological parameters and adjuvant radiotherapy (aRT) on ACC disease specific (DSS) and overall survival (OS). We extracted demographic, treatment, and survival information of 1439 patients with major or minor intraoral salivary gland ACC from the Surveillance, Epidemiology, and End Results (SEER) database. The associations between tumor characteristics and aRT with OS and DSS were estimated using hazard ratios (HR) and 95% confidence intervals (CI). Submandibular gland ACCs had the worst prognosis (adjusted DSS HR = 1.48; 95% CI = 0.99–2.20, compared to parotid), and this difference was more pronounced among patients with advanced-stage tumors (adjusted DSS HR = 1.93; 95% CI = 1.13–3.30). aRT was associated with increased overall survival only among stage III submandibular ACC patients (HR = 0.64; 95% CI = 0.42–0.98) and had no benefit in any other group. In conclusion, submandibular gland ACC carries a worse prognosis than other gland subsites and may benefit from aRT. The different outcomes between submandibular gland and other major or minor gland ACCs warrant further mechanistic investigation.https://www.mdpi.com/2072-6694/13/4/589adenoid cystic carcinomaadjuvant radiotherapysubmandibular salivary glandprognosissurveillance, epidemiology, and end results (SEER) database |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jason Tasoulas Kimon Divaris Stamatios Theocharis Douglas Farquhar Colette Shen Trevor Hackman Antonio L. Amelio |
spellingShingle |
Jason Tasoulas Kimon Divaris Stamatios Theocharis Douglas Farquhar Colette Shen Trevor Hackman Antonio L. Amelio Impact of Tumor Site and Adjuvant Radiotherapy on Survival of Patients with Adenoid Cystic Carcinoma: A SEER Database Analysis Cancers adenoid cystic carcinoma adjuvant radiotherapy submandibular salivary gland prognosis surveillance, epidemiology, and end results (SEER) database |
author_facet |
Jason Tasoulas Kimon Divaris Stamatios Theocharis Douglas Farquhar Colette Shen Trevor Hackman Antonio L. Amelio |
author_sort |
Jason Tasoulas |
title |
Impact of Tumor Site and Adjuvant Radiotherapy on Survival of Patients with Adenoid Cystic Carcinoma: A SEER Database Analysis |
title_short |
Impact of Tumor Site and Adjuvant Radiotherapy on Survival of Patients with Adenoid Cystic Carcinoma: A SEER Database Analysis |
title_full |
Impact of Tumor Site and Adjuvant Radiotherapy on Survival of Patients with Adenoid Cystic Carcinoma: A SEER Database Analysis |
title_fullStr |
Impact of Tumor Site and Adjuvant Radiotherapy on Survival of Patients with Adenoid Cystic Carcinoma: A SEER Database Analysis |
title_full_unstemmed |
Impact of Tumor Site and Adjuvant Radiotherapy on Survival of Patients with Adenoid Cystic Carcinoma: A SEER Database Analysis |
title_sort |
impact of tumor site and adjuvant radiotherapy on survival of patients with adenoid cystic carcinoma: a seer database analysis |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-02-01 |
description |
Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor, displaying aggressive behavior with frequent recurrence and metastasis. Little information exists regarding the impact of clinicopathological parameters and adjuvant radiotherapy (aRT) on ACC disease specific (DSS) and overall survival (OS). We extracted demographic, treatment, and survival information of 1439 patients with major or minor intraoral salivary gland ACC from the Surveillance, Epidemiology, and End Results (SEER) database. The associations between tumor characteristics and aRT with OS and DSS were estimated using hazard ratios (HR) and 95% confidence intervals (CI). Submandibular gland ACCs had the worst prognosis (adjusted DSS HR = 1.48; 95% CI = 0.99–2.20, compared to parotid), and this difference was more pronounced among patients with advanced-stage tumors (adjusted DSS HR = 1.93; 95% CI = 1.13–3.30). aRT was associated with increased overall survival only among stage III submandibular ACC patients (HR = 0.64; 95% CI = 0.42–0.98) and had no benefit in any other group. In conclusion, submandibular gland ACC carries a worse prognosis than other gland subsites and may benefit from aRT. The different outcomes between submandibular gland and other major or minor gland ACCs warrant further mechanistic investigation. |
topic |
adenoid cystic carcinoma adjuvant radiotherapy submandibular salivary gland prognosis surveillance, epidemiology, and end results (SEER) database |
url |
https://www.mdpi.com/2072-6694/13/4/589 |
work_keys_str_mv |
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