Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References
The use of event-related potential (ERP) recording technology during perceptual and cognitive processing has been studied in order to develop objective diagnostic indexes for people with neuropsychiatric disorders. For example, patients with schizophrenia exhibit consistent abnormalities in face-evo...
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doaj-6d53a9d4ae6c404cb10d1d94b7e71b6e2020-11-24T22:15:11ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2017-05-011110.3389/fnins.2017.00314263914Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different ReferencesShenglin She0Haijing Li1Yuping Ning2Jianjuan Ren3Zhangying Wu4Rongcheng Huang5Jingping Zhao6Jingping Zhao7Qian Wang8Yingjun Zheng9Department of General Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)Guangzhou, ChinaDepartment of General Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)Guangzhou, ChinaDepartment of General Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)Guangzhou, ChinaDepartment of General Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)Guangzhou, ChinaDepartment of General Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)Guangzhou, ChinaDepartment of General Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)Guangzhou, ChinaDepartment of General Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)Guangzhou, ChinaNational Clinical Research Center for Mental Disorders, Mental Health Institute, The Second Xiangya Hospital of Central South UniversityChangsha, ChinaBeijing Key Laboratory of Epilepsy, Department of Functional Neurosurgery, Epilepsy Center, Sanbo Brain Hospital, Capital Medical UniversityBeijing, ChinaDepartment of General Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)Guangzhou, ChinaThe use of event-related potential (ERP) recording technology during perceptual and cognitive processing has been studied in order to develop objective diagnostic indexes for people with neuropsychiatric disorders. For example, patients with schizophrenia exhibit consistent abnormalities in face-evoked early components of ERPs and mismatch negativities (MMNs). In most studies, the choice of reference has been the average reference (AVE), but whether this is the most suitable choice is still unknown. The aim of this study was to systematically compare the AVE and reference electrode standardization technique (REST) methods for assessing expressional face-evoked early visual ERPs and visual MMNs (vMMNs) in patients with schizophrenia and healthy controls. The results showed that both the AVE and REST methods could: (1) obtain primary visual-evoked ERPs in the two groups, (2) reveal the neutral and emotional expression discrimination deficit of the P1 component in the patients, which was normal in the healthy controls, (3) reflect reductions of happy vMMNs in the patients compared to the healthy controls, and (4) show right-dominant sad vMMNs only in the patients. On the other hand, compared to the energy distributions of the AVE-obtained potentials, those of REST-obtained early visual ERPs and vMMNs were more concentrated around the temporo-occipital areas. Furthermore, only the REST-obtained vMMNs revealed a significant difference between happy and sad mismatch stimuli in patients with schizophrenia. These results demonstrate that REST technology might provide new insights into neurophysiological factors associated with neuropsychiatric disorders.http://journal.frontiersin.org/article/10.3389/fnins.2017.00314/fullschizophreniafacial expressionvisual mismatch negativity (vMMN)average reference (AVE)reference electrode standardization technique (REST) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shenglin She Haijing Li Yuping Ning Jianjuan Ren Zhangying Wu Rongcheng Huang Jingping Zhao Jingping Zhao Qian Wang Yingjun Zheng |
spellingShingle |
Shenglin She Haijing Li Yuping Ning Jianjuan Ren Zhangying Wu Rongcheng Huang Jingping Zhao Jingping Zhao Qian Wang Yingjun Zheng Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References Frontiers in Neuroscience schizophrenia facial expression visual mismatch negativity (vMMN) average reference (AVE) reference electrode standardization technique (REST) |
author_facet |
Shenglin She Haijing Li Yuping Ning Jianjuan Ren Zhangying Wu Rongcheng Huang Jingping Zhao Jingping Zhao Qian Wang Yingjun Zheng |
author_sort |
Shenglin She |
title |
Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References |
title_short |
Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References |
title_full |
Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References |
title_fullStr |
Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References |
title_full_unstemmed |
Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References |
title_sort |
revealing the dysfunction of schematic facial-expression processing in schizophrenia: a comparative study of different references |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2017-05-01 |
description |
The use of event-related potential (ERP) recording technology during perceptual and cognitive processing has been studied in order to develop objective diagnostic indexes for people with neuropsychiatric disorders. For example, patients with schizophrenia exhibit consistent abnormalities in face-evoked early components of ERPs and mismatch negativities (MMNs). In most studies, the choice of reference has been the average reference (AVE), but whether this is the most suitable choice is still unknown. The aim of this study was to systematically compare the AVE and reference electrode standardization technique (REST) methods for assessing expressional face-evoked early visual ERPs and visual MMNs (vMMNs) in patients with schizophrenia and healthy controls. The results showed that both the AVE and REST methods could: (1) obtain primary visual-evoked ERPs in the two groups, (2) reveal the neutral and emotional expression discrimination deficit of the P1 component in the patients, which was normal in the healthy controls, (3) reflect reductions of happy vMMNs in the patients compared to the healthy controls, and (4) show right-dominant sad vMMNs only in the patients. On the other hand, compared to the energy distributions of the AVE-obtained potentials, those of REST-obtained early visual ERPs and vMMNs were more concentrated around the temporo-occipital areas. Furthermore, only the REST-obtained vMMNs revealed a significant difference between happy and sad mismatch stimuli in patients with schizophrenia. These results demonstrate that REST technology might provide new insights into neurophysiological factors associated with neuropsychiatric disorders. |
topic |
schizophrenia facial expression visual mismatch negativity (vMMN) average reference (AVE) reference electrode standardization technique (REST) |
url |
http://journal.frontiersin.org/article/10.3389/fnins.2017.00314/full |
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