A non-destructive NIR spectroscopic method combined with chemometry for simultaneous assay of paracetamol and caffeine in tablets

A non-destructive NIR spectroscopic method combined with chemometry for simultaneous assay of paracetamol and caffeine in tablets

The use of near infrared (NIR) spectroscopy to predict the concentration of two active pharmaceutical ingredients (APIs), paracetamol and caffeine, in intact tablets, has been evaluated in this study. A partial least squares (PLS) regression model was developed using spectral data obtained on a cali...

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Bibliographic Details
Main Authors: Dana MUNTEAN, Alina PORFIRE, Cristian ALECU, Sonia IURIAN, Tibor CASIAN, Alexandru GÂVAN, Ioan TOMUTA
Format: Article
Language:English
Published: Amaltea Medical Publishing House 2021-06-01
Series:Romanian Journal of Pharmaceutical Practice
Subjects:
nir spectroscopy
chemometry
paracetamol
caffeine
tablets
api assay
Online Access:https://farma.com.ro/articles/2021.2/RJPhP_2021_2_Art-02.pdf

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