Myriocin significantly increases the mortality of a non-mammalian model host during Candida pathogenesis.
Candida albicans is a major human pathogen whose treatment is challenging due to antifungal drug toxicity, drug resistance and paucity of antifungal agents available. Myrocin (MYR) inhibits sphingosine synthesis, a precursor of sphingolipids, an important cell membrane and signaling molecule compone...
Main Authors: | Nadja Rodrigues de Melo, Ahmed Abdrahman, Carolyn Greig, Krishnendu Mukherjee, Catherine Thornton, Norman A Ratcliffe, Andreas Vilcinskas, Tariq M Butt |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260135/pdf/?tool=EBI |
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