Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes

Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes

We generated induced excitatory neurons (iNeurons, iNs) from chimpanzee, bonobo, and human stem cells by expressing the transcription factor neurogenin-2 (NGN2). Single-cell RNA sequencing showed that genes involved in dendrite and synapse development are expressed earlier during iNs maturation in t...

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Bibliographic Details
Main Authors: Maria Schörnig, Xiangchun Ju, Luise Fast, Sebastian Ebert, Anne Weigert, Sabina Kanton, Theresa Schaffer, Nael Nadif Kasri, Barbara Treutlein, Benjamin Marco Peter, Wulf Hevers, Elena Taverna
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
Chimpanzee
bonobo
neuronal maturation
neurodevelopment
neuronal function
evolution
Online Access:https://elifesciences.org/articles/59323

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