Different contribution of redox-sensitive transient receptor potential channels to acetaminophen-induced death of human hepatoma cell line.

Different contribution of redox-sensitive transient receptor potential channels to acetaminophen-induced death of human hepatoma cell line.

Acetaminophen (APAP) is a safe analgesic antipyretic drug at prescribed doses. Its overdose, however, can cause life-threatening liver damage. Though involvement of oxidative stress is widely acknowledged in APAP-induced hepatocellular death, the mechanism of this increased oxidative stress and the...

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Bibliographic Details
Main Authors: Heba eBadr, Daisuke eKozai, Reiko eSakaguchi, Tomohiro eNumata, Yasuo eMori
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Pharmacology
Subjects:
Acetaminophen
Oxidative Stress
TRP channels
cell death.
HepG2
Ca2+ entry
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00019/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00019/full

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