Obstacles to early treatment of idiopathic pulmonary fibrosis: current perspectives
Teng Moua, Jay H Ryu Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester MN, USA Abstract: Idiopathic pulmonary fibrosis is a progressive and fatal fibrotic lung disease which has seen new opportunity for drug treatment in the last several year...
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doaj-6d8dfc4d676e41e4a138521be5faaaba2020-11-24T22:16:31ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2019-01-01Volume 15738143403Obstacles to early treatment of idiopathic pulmonary fibrosis: current perspectivesMoua TRyu JHTeng Moua, Jay H Ryu Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester MN, USA Abstract: Idiopathic pulmonary fibrosis is a progressive and fatal fibrotic lung disease which has seen new opportunity for drug treatment in the last several years with the approval of nintedanib and pirfenidone, two antifibrotic agents aimed at slowing decline in lung function as defined by FVC on pulmonary function testing. Despite these promising effects, delays in drug initiation have been reported undermining the premise that earlier drug initiation may sustain lung function and prolong survival. This review explores obstacles to earlier treatment, inclusive of defining so-called early idiopathic pulmonary fibrosis, difficulties in achieving a confident diagnosis in that setting, and uncertainties regarding drug-related benefits among specific patient subgroups such as those with no symptoms or advanced disease at presentation. Goals of therapy balanced with the burdens associated with antifibrotic drug therapy are negotiated on an individual basis. We review the evidence for and against earlier initiation of antifibrotic drug therapy along with its role in patient-centered outcomes. Keywords: idiopathic pulmonary fibrosis, nintedanib, pirfenidone, antifibroticshttps://www.dovepress.com/obstacles-to-early-treatment-of-idiopathic-pulmonary-fibrosis-current--peer-reviewed-article-TCRMidiopathic pulmonary fibrosisnintedanibpirfenidoneanti-fibrotics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Moua T Ryu JH |
spellingShingle |
Moua T Ryu JH Obstacles to early treatment of idiopathic pulmonary fibrosis: current perspectives Therapeutics and Clinical Risk Management idiopathic pulmonary fibrosis nintedanib pirfenidone anti-fibrotics |
author_facet |
Moua T Ryu JH |
author_sort |
Moua T |
title |
Obstacles to early treatment of idiopathic pulmonary fibrosis: current perspectives |
title_short |
Obstacles to early treatment of idiopathic pulmonary fibrosis: current perspectives |
title_full |
Obstacles to early treatment of idiopathic pulmonary fibrosis: current perspectives |
title_fullStr |
Obstacles to early treatment of idiopathic pulmonary fibrosis: current perspectives |
title_full_unstemmed |
Obstacles to early treatment of idiopathic pulmonary fibrosis: current perspectives |
title_sort |
obstacles to early treatment of idiopathic pulmonary fibrosis: current perspectives |
publisher |
Dove Medical Press |
series |
Therapeutics and Clinical Risk Management |
issn |
1178-203X |
publishDate |
2019-01-01 |
description |
Teng Moua, Jay H Ryu Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester MN, USA Abstract: Idiopathic pulmonary fibrosis is a progressive and fatal fibrotic lung disease which has seen new opportunity for drug treatment in the last several years with the approval of nintedanib and pirfenidone, two antifibrotic agents aimed at slowing decline in lung function as defined by FVC on pulmonary function testing. Despite these promising effects, delays in drug initiation have been reported undermining the premise that earlier drug initiation may sustain lung function and prolong survival. This review explores obstacles to earlier treatment, inclusive of defining so-called early idiopathic pulmonary fibrosis, difficulties in achieving a confident diagnosis in that setting, and uncertainties regarding drug-related benefits among specific patient subgroups such as those with no symptoms or advanced disease at presentation. Goals of therapy balanced with the burdens associated with antifibrotic drug therapy are negotiated on an individual basis. We review the evidence for and against earlier initiation of antifibrotic drug therapy along with its role in patient-centered outcomes. Keywords: idiopathic pulmonary fibrosis, nintedanib, pirfenidone, antifibrotics |
topic |
idiopathic pulmonary fibrosis nintedanib pirfenidone anti-fibrotics |
url |
https://www.dovepress.com/obstacles-to-early-treatment-of-idiopathic-pulmonary-fibrosis-current--peer-reviewed-article-TCRM |
work_keys_str_mv |
AT mouat obstaclestoearlytreatmentofidiopathicpulmonaryfibrosiscurrentperspectives AT ryujh obstaclestoearlytreatmentofidiopathicpulmonaryfibrosiscurrentperspectives |
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1716572202051043328 |