RIP140 Represses Intestinal Paneth Cell Differentiation and Interplays with SOX9 Signaling in Colorectal Cancer

RIP140 Represses Intestinal Paneth Cell Differentiation and Interplays with SOX9 Signaling in Colorectal Cancer

RIP140 is a major transcriptional coregulator of gut homeostasis and tumorigenesis through the regulation of Wnt/APC signaling. Here, we investigated the effect of RIP140 on Paneth cell differentiation and its interplay with the transcription factor SOX9. Using loss of function mouse models, human c...

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Bibliographic Details
Main Authors: Antoine Gleizes, Mouna Triki, Sandrine Bonnet, Naomi Baccari, Gabriel Jimenez-Dominguez, Aurélie Covinhes, Nelly Pirot, Philippe Blache, Rong Yuan, Balázs Győrffy, Vincent Cavaillès, Marion Lapierre
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
intestinal epithelium
cell differentiation
colon cancer
RIP140
SOX9
transcriptional regulation
Online Access:https://www.mdpi.com/2072-6694/13/13/3192

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