Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children
Objectives: The World Health Organization recommends a 2-dose rabies pre-exposure prophylaxis (PrEP) regimen. This study aimed to compare the immunogenicity of rabies PrEP regimens co-administered with inactivated quadrivalent influenza vaccine (IIV4). Methods: Children aged 3 to 9 years were random...
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2021-11-01
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doaj-6d9801c6b7bc4308b1f59922fb6dcaa42021-10-09T04:37:06ZengElsevierInternational Journal of Infectious Diseases1201-97122021-11-011128995Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in childrenNapaporn Chantasrisawad0Watsamon Jantarabenjakul1Suvaporn Anugulruengkitt2Suda Punrin3Kornvika Limsuwun4Panadda Sawangsinth5Chayapa Phasomsap6Jiratchaya Sophonphan7Chitsanu Pancharoen8Thanyawee Puthanakit9Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Thai Red Cross Emerging Infectious Diseases Clinical Center (TRC-EID), King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Corresponding author at: Watsamon Jantarabenjakul, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Bangkok 10330, Thailand.Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandQueen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok, ThailandQueen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok, ThailandCenter of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandObjectives: The World Health Organization recommends a 2-dose rabies pre-exposure prophylaxis (PrEP) regimen. This study aimed to compare the immunogenicity of rabies PrEP regimens co-administered with inactivated quadrivalent influenza vaccine (IIV4). Methods: Children aged 3 to 9 years were randomly assigned (2:2:1) to receive 0.25 mL of chromatographically purified Vero cell rabies vaccine intramuscularly: Group A at day 0, 7 with IIV4; Group B at day 0, 28 with IIV4; Group C at day 0, 7. A booster-dose of CPRV was given on day 365. Primary outcome was the proportion of children with protective rabies virus neutralizing antibody (RVNA) ≥ 0.5 IU/mL, on day 42 and 7 days post-booster. Results: From November 2019 to January 2020; 100 children with a median age (IQR) of 5.4 years (4.8-7.3) were enrolled. All participants achieved protective RVNA titers on day 42 and 7-days post booster. Geometric mean titers (GMT) at day 42 were Group A, 8.98(95%CI 7.06-11.42); Group B, 23.89(95%CI 19.33-29.51); Group C, 9.94(95%CI 7.03-14.06). Likewise, RVNA GMT at 7 days post-booster were Group A, 42.53(95%CI 18.41-66.64); Group B, 23.19(95%CI 17.28-29.10); Group C, 57.75 (95%CI 35.86-79.67). Conclusions: The 2-dose PrEP regimen of rabies vaccine produces adequate immune response either 0,7 or 0, 28 regimens.http://www.sciencedirect.com/science/article/pii/S1201971221007360Rabies vaccinePre-exposure rabies prophylaxisInactivated quadrivalent influenza vaccineChildren |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Napaporn Chantasrisawad Watsamon Jantarabenjakul Suvaporn Anugulruengkitt Suda Punrin Kornvika Limsuwun Panadda Sawangsinth Chayapa Phasomsap Jiratchaya Sophonphan Chitsanu Pancharoen Thanyawee Puthanakit |
spellingShingle |
Napaporn Chantasrisawad Watsamon Jantarabenjakul Suvaporn Anugulruengkitt Suda Punrin Kornvika Limsuwun Panadda Sawangsinth Chayapa Phasomsap Jiratchaya Sophonphan Chitsanu Pancharoen Thanyawee Puthanakit Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children International Journal of Infectious Diseases Rabies vaccine Pre-exposure rabies prophylaxis Inactivated quadrivalent influenza vaccine Children |
author_facet |
Napaporn Chantasrisawad Watsamon Jantarabenjakul Suvaporn Anugulruengkitt Suda Punrin Kornvika Limsuwun Panadda Sawangsinth Chayapa Phasomsap Jiratchaya Sophonphan Chitsanu Pancharoen Thanyawee Puthanakit |
author_sort |
Napaporn Chantasrisawad |
title |
Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
title_short |
Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
title_full |
Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
title_fullStr |
Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
title_full_unstemmed |
Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
title_sort |
immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2021-11-01 |
description |
Objectives: The World Health Organization recommends a 2-dose rabies pre-exposure prophylaxis (PrEP) regimen. This study aimed to compare the immunogenicity of rabies PrEP regimens co-administered with inactivated quadrivalent influenza vaccine (IIV4). Methods: Children aged 3 to 9 years were randomly assigned (2:2:1) to receive 0.25 mL of chromatographically purified Vero cell rabies vaccine intramuscularly: Group A at day 0, 7 with IIV4; Group B at day 0, 28 with IIV4; Group C at day 0, 7. A booster-dose of CPRV was given on day 365. Primary outcome was the proportion of children with protective rabies virus neutralizing antibody (RVNA) ≥ 0.5 IU/mL, on day 42 and 7 days post-booster. Results: From November 2019 to January 2020; 100 children with a median age (IQR) of 5.4 years (4.8-7.3) were enrolled. All participants achieved protective RVNA titers on day 42 and 7-days post booster. Geometric mean titers (GMT) at day 42 were Group A, 8.98(95%CI 7.06-11.42); Group B, 23.89(95%CI 19.33-29.51); Group C, 9.94(95%CI 7.03-14.06). Likewise, RVNA GMT at 7 days post-booster were Group A, 42.53(95%CI 18.41-66.64); Group B, 23.19(95%CI 17.28-29.10); Group C, 57.75 (95%CI 35.86-79.67). Conclusions: The 2-dose PrEP regimen of rabies vaccine produces adequate immune response either 0,7 or 0, 28 regimens. |
topic |
Rabies vaccine Pre-exposure rabies prophylaxis Inactivated quadrivalent influenza vaccine Children |
url |
http://www.sciencedirect.com/science/article/pii/S1201971221007360 |
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