Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents
BackgroundBisphenol F (BPF) and bisphenol S (BPS) are increasingly used as substitutes for bisphenol A (BPA), an environmental obesogen. However, health effects of BPF and BPS remain unclear. In this study, we evaluated the associations of BPA, BPF, and BPS with obesity in children and adolescents.M...
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Korean Diabetes Association
2019-02-01
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doaj-6d9e403c9119449c90ed0f397da995272020-11-25T01:31:21ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872019-02-01431597510.4093/dmj.2018.0045Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and AdolescentsBuyun Liu0Hans-Joachim Lehmler1Yangbo Sun2Guifeng Xu3Qi Sun4Linda G. Snetselaar5Robert B. Wallace6Wei Bao7Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, .USADepartment of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA, .USADepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, .USADepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, .USADepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, .USADepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, .USADepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, .USADepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, .USABackgroundBisphenol F (BPF) and bisphenol S (BPS) are increasingly used as substitutes for bisphenol A (BPA), an environmental obesogen. However, health effects of BPF and BPS remain unclear. In this study, we evaluated the associations of BPA, BPF, and BPS with obesity in children and adolescents.MethodsWe used data from the U.S. National Health and Nutrition Examination Survey 2013 to 2014, a nationally representative study. We included 745 participants aged 6 to 17 years old. General obesity was defined based on the 2000 Centers for Disease Control and Prevention body mass index-for-age growth charts for the United States. Abdominal obesity was defined as waist-to-height ratio ≥0.5.ResultsAfter adjustment for demographic, socioeconomic and lifestyle factors, and urinary creatinine levels, the odds ratio of general obesity comparing the highest with lowest quartile of urinary bisphenol levels was 1.74 (95% confidence interval [CI], 0.92 to 3.31) for BPA, 1.54 (95% CI, 1.02 to 2.32) for BPF, and 1.36 (95% CI, 0.53 to 3.51) for BPS. Moreover, the associations were stronger in boys than in girls for BPA and BPF. Similar results were observed for abdominal obesity.ConclusionThis study for the first time showed that exposure to BPF, a commonly used substitute for BPA, was positively associated with higher risk of obesity in children and adolescents. The association of BPA and BPF with general and abdominal obesity was primarily observed in boys, suggesting a possible sex difference. Further investigations on the underlying mechanisms are needed.https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-43-59.pdfAdolescentBisphenol ABisphenol FBis(4-hydroxyphenyl)sulfoneChildObesity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Buyun Liu Hans-Joachim Lehmler Yangbo Sun Guifeng Xu Qi Sun Linda G. Snetselaar Robert B. Wallace Wei Bao |
spellingShingle |
Buyun Liu Hans-Joachim Lehmler Yangbo Sun Guifeng Xu Qi Sun Linda G. Snetselaar Robert B. Wallace Wei Bao Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents Diabetes & Metabolism Journal Adolescent Bisphenol A Bisphenol F Bis(4-hydroxyphenyl)sulfone Child Obesity |
author_facet |
Buyun Liu Hans-Joachim Lehmler Yangbo Sun Guifeng Xu Qi Sun Linda G. Snetselaar Robert B. Wallace Wei Bao |
author_sort |
Buyun Liu |
title |
Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents |
title_short |
Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents |
title_full |
Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents |
title_fullStr |
Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents |
title_full_unstemmed |
Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents |
title_sort |
association of bisphenol a and its substitutes, bisphenol f and bisphenol s, with obesity in united states children and adolescents |
publisher |
Korean Diabetes Association |
series |
Diabetes & Metabolism Journal |
issn |
2233-6079 2233-6087 |
publishDate |
2019-02-01 |
description |
BackgroundBisphenol F (BPF) and bisphenol S (BPS) are increasingly used as substitutes for bisphenol A (BPA), an environmental obesogen. However, health effects of BPF and BPS remain unclear. In this study, we evaluated the associations of BPA, BPF, and BPS with obesity in children and adolescents.MethodsWe used data from the U.S. National Health and Nutrition Examination Survey 2013 to 2014, a nationally representative study. We included 745 participants aged 6 to 17 years old. General obesity was defined based on the 2000 Centers for Disease Control and Prevention body mass index-for-age growth charts for the United States. Abdominal obesity was defined as waist-to-height ratio ≥0.5.ResultsAfter adjustment for demographic, socioeconomic and lifestyle factors, and urinary creatinine levels, the odds ratio of general obesity comparing the highest with lowest quartile of urinary bisphenol levels was 1.74 (95% confidence interval [CI], 0.92 to 3.31) for BPA, 1.54 (95% CI, 1.02 to 2.32) for BPF, and 1.36 (95% CI, 0.53 to 3.51) for BPS. Moreover, the associations were stronger in boys than in girls for BPA and BPF. Similar results were observed for abdominal obesity.ConclusionThis study for the first time showed that exposure to BPF, a commonly used substitute for BPA, was positively associated with higher risk of obesity in children and adolescents. The association of BPA and BPF with general and abdominal obesity was primarily observed in boys, suggesting a possible sex difference. Further investigations on the underlying mechanisms are needed. |
topic |
Adolescent Bisphenol A Bisphenol F Bis(4-hydroxyphenyl)sulfone Child Obesity |
url |
https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-43-59.pdf |
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