Mutation of the ATPase Domain of MutS Homolog-5 (MSH5) Reveals a Requirement for a Functional MutSγ Complex for All Crossovers in Mammalian Meiosis

Mutation of the ATPase Domain of MutS Homolog-5 (MSH5) Reveals a Requirement for a Functional MutSγ Complex for All Crossovers in Mammalian Meiosis

During meiosis, induction of DNA double strand breaks (DSB) leads to recombination between homologous chromosomes, resulting in crossovers (CO) and non-crossovers (NCO). In the mouse, only 10% of DSBs resolve as COs, mostly through a class I pathway dependent on MutSγ (MSH4/ MSH5) and MutLγ (MLH1/ML...

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Bibliographic Details
Main Authors: Carolyn R. Milano, J. Kim Holloway, Yongwei Zhang, Bo Jin, Cameron Smith, Aviv Bergman, Winfried Edelmann, Paula E. Cohen
Format: Article
Language:English
Published: Oxford University Press 2019-06-01
Series:G3: Genes, Genomes, Genetics
Subjects:
MutS homolog
meiosis
mouse
crossing over
homologous recombination
crossover designation
prophase I
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400074

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