AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE−/− mice

AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE−/− mice

HDL plays crucial roles at multiple stages of the pathogenesis of atherosclerosis. AMP-activated protein kinase (AMPK) is a therapeutic candidate for the treatment of cardiovascular disease. However, the effect of AMPK activation on HDL functionality has not been established in vivo. We assessed the...

Full description

Bibliographic Details
Main Authors:	Ang Ma, Jing Wang, Liu Yang, Yuanyuan An, Haibo Zhu
Format:	Article
Language:	English
Published:	Elsevier 2017-08-01
Series:	Journal of Lipid Research
Subjects:	adenosine monophosphate-activated protein kinase atherosclerosis reverse cholesterol transport apolipoprotein E deficient
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520337810

Similar Items

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk
by: Morgan D. Fullerton, et al.
Published: (2015-05-01)

Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice
by: Nicholas D. LeBlond, et al.
Published: (2020-12-01)

ApoA-I Milano stimulates lipolysis in adipose cells independently of cAMP/PKA activation
by: Maria Lindahl, et al.
Published: (2015-12-01)

Antisense inhibition of apoB synthesis with mipomersen reduces plasma apoC-III and apoC-III-containing lipoproteins
by: Jeremy D. Furtado, et al.
Published: (2012-04-01)

Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue
by: X. Julia Xu, et al.
Published: (2012-04-01)

High hydrostatic pressure extract of mulberry leaves ameliorates hypercholesterolemia via modulating hepatic microRNA-33 expression and AMPK activity in high cholesterol diet fed rats
by: Eunyoung Lee, et al.
Published: (2021-05-01)

Deletion of the propeptide of apolipoprotein A-I reduces protein expression but stimulates effective conversion of preβ-high density lipoprotein to α-high density lipoprotein
by: Dmitri Sviridov, et al.
Published: (2000-11-01)

Storage of human plasma samples leads to alterations in the lipoprotein distribution of apoC-III and apoE
by: Jeffrey S. Cohn, et al.
Published: (2004-08-01)

Effect of Teucrium polium leaf extracts on AMPK level in Isolated Rat Pancreases
by: Durdi Qujeq, et al.
Published: (2013-11-01)

The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK[S]
by: Nadya M. Morrow, et al.
Published: (2020-03-01)

AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice
by: Anne-Emilie Declèves, et al.
Published: (2019-05-01)

Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice
by: DongFang Wu, et al.
Published: (2005-07-01)

Atherogenic, enlarged, and dysfunctional HDL in human PLTP/apoA-I double transgenic mice
by: Matthijs Moerland, et al.
Published: (2007-12-01)

AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma
by: Nicolas Belforte, et al.
Published: (2021-06-01)

Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver
by: Xiujuan Zhang, et al.
Published: (2015-05-01)

Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux[S]
by: David Meriwether, et al.
Published: (2016-07-01)

Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein
by: Carlos L.J. Vrins, et al.
Published: (2012-10-01)

Penicilliumin B Protects against Cisplatin-Induced Renal Tubular Cell Apoptosis through Activation of AMPK-Induced Autophagy and Mitochondrial Biogenesis
by: Weiwei Shen, et al.
Published: (2021-04-01)

Peptides derived from serum amyloid A prevent, and reverse, aortic lipid lesions in apoE−/− mice
by: Shui Pang Tam, et al.
Published: (2005-10-01)

Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance
by: Baile Wang, et al.
Published: (2018-11-01)

Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cellss⃞
by: Chih-Li Lin, et al.
Published: (2007-11-01)

Periodontitis decreases the antiatherogenic potency of high density lipoprotein
by: Pirkko J. Pussinen, et al.
Published: (2004-01-01)

ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity
by: Márcia Almeida Liz, et al.
Published: (2007-11-01)

Identification of Direct Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Structure-Based Virtual Screening and Molecular Docking Approach
by: Tonghui Huang, et al.
Published: (2017-06-01)

Small dense low density lipoprotein has increased affinity for LDL receptor-independent cell surface binding sites: a potential mechanism for increased atherogenicity1
by: Narmer F. Galeano, et al.
Published: (1998-06-01)

Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice
by: Hiroaki Yagyu, et al.
Published: (1999-09-01)

Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapy
by: D Dutta, et al.
Published: (2017-01-01)

Effect of adenosine monophosphate‐activated protein kinase–p53–Krüppel‐like factor 2a pathway in hyperglycemia‐induced cardiac remodeling in adult zebrafish
by: Qiuyun Wang, et al.
Published: (2021-03-01)

A comparison of LKB1/AMPK/mTOR metabolic axis response to global ischaemia in brain, heart, liver and kidney in a rat model of cardiac arrest
by: Shohreh Majd, et al.
Published: (2018-06-01)

High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins
by: Matthias Schneider, et al.
Published: (2005-04-01)

Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver
by: Eun-Jeong Jung, et al.
Published: (2011-09-01)

Proteomic analysis of electronegative low-density lipoprotein[S]
by: Cristina Bancells, et al.
Published: (2010-12-01)

Cholesterol Activates Cyclic AMP Signaling in Metaplastic Acinar Cells
by: Francesca Grisan, et al.
Published: (2021-02-01)

Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice
by: Songtao Li, et al.
Published: (2020-11-01)

Comparing Effect of Aaerobic and Resistance Training on Profile of Apolipoprotein and Lipoprotein in Overweight Females
by: A Saadatnia, et al.
Published: (2015-05-01)

Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs
by: Jeong Shim, MD, et al.
Published: (2017-10-01)

Structure-function studies of apoA-I variants:site-directed mutagenesis and natural mutations
by: Dmitri Sviridov, et al.
Published: (2002-08-01)

Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation
by: Jae Yun Han, et al.
Published: (2015-04-01)

Human apolipoprotein A-II is a pro-atherogenic molecule when it is expressed in transgenic mice at a level similar to that in humans: evidence of a potentially relevant species-specific interaction with diet
by: Joan Carles Escolà-Gil, et al.
Published: (1998-02-01)

Impaired nicotinamide adenine dinucleotide (NAD+) metabolism in diabetes and diabetic tissues: Implications for nicotinamide‐related compound treatment
by: Lan Fan, et al.
Published: (2020-11-01)