Modern Approach in Premature Ovarian Failure

• Main Authors: Pacu Irina, Ionescu Cringu, Serafinceanu Cristian, Pantea-Stoian Anca Mihaela, Elian Viviana
• Format: Article
• Language: English
• Published: Sciendo 2014-09-01
• Series: Romanian Journal of Diabetes Nutrition and Metabolic Diseases
• Subjects: premature ovarian failure; estrogen deprivation; autoimmune etiology; infertility; hormonal substitution
• Online Access: https://doi.org/10.2478/rjdnmd-2014-0028

Premature ovarian failure (POF) is a condition affecting 1-2% of women younger than 40 years of age, characterized by amenorrhea, hypoestrogenism and elevated gonadotropin levels. In the last years it became a problem of social health interest as the frequency increased due to environmental factors and new, efficient methods for cancer treatment in young women. Few genes have beed identified to explain cases of POF but there are also autoimmune associated conditions and an increasing number of iatrogenic cases (chemotherapy, surgery, radiotherapy). Modern approach in POF means not only a precise etiological diagnosis, but also a correct counseling for these patients who often want to become parents, and a chance for a healthy life without the long term consequences of estrogen deprivation from an early age. In vitro fertilization (IVF) techniques can be useful for certain cases but research is needed on strategies to improve fertility for women who have follicles remaining in the ovaries.