Correlation between pretreatment serum LDL-cholesterol levels and prognosis in nasopharyngeal carcinoma patients
Qiu Tang, Qiao-Ying Hu, Yong-feng Piao, Yong-Hong Hua Department of Head and Neck Cancer Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People’s Republic of China Purpose: To investigate the correlations between long-term survival outcomes in patients with nasopharyngeal car...
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doaj-6dc339af0c074c779549a9b495b2f0712020-11-25T01:23:25ZengDove Medical PressOncoTargets and Therapy1178-69302016-05-012016Issue 12585259126719Correlation between pretreatment serum LDL-cholesterol levels and prognosis in nasopharyngeal carcinoma patientsTang QHu QYPiao YFHua YHQiu Tang, Qiao-Ying Hu, Yong-feng Piao, Yong-Hong Hua Department of Head and Neck Cancer Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People’s Republic of China Purpose: To investigate the correlations between long-term survival outcomes in patients with nasopharyngeal carcinoma (NPC) and pretreatment serum low-density lipoprotein cholesterol (LDL-C) levels. Patients and methods: Between January 2008 and December 2011, 935 patients with newly diagnosed NPC who were treated with intensity-modulated radiation therapy were included in this retrospective clinical analysis. Patients were divided into two groups based on pretreatment LDL-C levels: normal LDL-C (≤3.64 mmol/L; n=816) and elevated LDL-C (>3.64 mmol/L; n=119). Associations between pretreatment LDL-C levels and treatment outcome were analyzed by univariate and multivariate analyses. Results: The overall patient follow-up rate was 95.1%, and 726 patients received more than 5 years of follow-up. Five-year overall survival (OS), local control (LC), and distant metastasis-free survival (DMFS) rates of the entire patient population were 87.1%, 91.1%, and 87.2%, respectively. Rates of 5-year OS, LC, and DMFS for the elevated versus normal LDL-C groups were 77.0% vs 89.1% (P<0.001), 85.8% vs 91.9% (P=0.041), and 81.1% vs 88.1% (P=0.038), respectively. Compared with normal LDL-C levels, elevated LDL-C levels were identified as an independent prognostic factor of a poorer OS (hazard ratio [HR] =2.171; 95% confidence interval [CI] =1.424–3.309), LC rate (HR =1.762; 95% CI =1.021–3.942), and DMFS (HR =1.594; 95% CI =1.003–2.532). Conclusion: This study found that elevated pretreatment LDL-C levels are negative prognostic indicators of NPC. Elevated LDL-C levels may be useful indicators of locoregional control and distant metastasis in NPC patients. Keywords: LDL-cholesterol, nasopharyngeal carcinoma, prognosishttps://www.dovepress.com/correlation-between-pretreatment-serum-ldl-cholesterol-levels-and-prog-peer-reviewed-article-OTTLDL-cholesterolnasopharyngeal carcinomaprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tang Q Hu QY Piao YF Hua YH |
spellingShingle |
Tang Q Hu QY Piao YF Hua YH Correlation between pretreatment serum LDL-cholesterol levels and prognosis in nasopharyngeal carcinoma patients OncoTargets and Therapy LDL-cholesterol nasopharyngeal carcinoma prognosis |
author_facet |
Tang Q Hu QY Piao YF Hua YH |
author_sort |
Tang Q |
title |
Correlation between pretreatment serum LDL-cholesterol levels and prognosis in nasopharyngeal carcinoma patients |
title_short |
Correlation between pretreatment serum LDL-cholesterol levels and prognosis in nasopharyngeal carcinoma patients |
title_full |
Correlation between pretreatment serum LDL-cholesterol levels and prognosis in nasopharyngeal carcinoma patients |
title_fullStr |
Correlation between pretreatment serum LDL-cholesterol levels and prognosis in nasopharyngeal carcinoma patients |
title_full_unstemmed |
Correlation between pretreatment serum LDL-cholesterol levels and prognosis in nasopharyngeal carcinoma patients |
title_sort |
correlation between pretreatment serum ldl-cholesterol levels and prognosis in nasopharyngeal carcinoma patients |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2016-05-01 |
description |
Qiu Tang, Qiao-Ying Hu, Yong-feng Piao, Yong-Hong Hua Department of Head and Neck Cancer Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People’s Republic of China Purpose: To investigate the correlations between long-term survival outcomes in patients with nasopharyngeal carcinoma (NPC) and pretreatment serum low-density lipoprotein cholesterol (LDL-C) levels. Patients and methods: Between January 2008 and December 2011, 935 patients with newly diagnosed NPC who were treated with intensity-modulated radiation therapy were included in this retrospective clinical analysis. Patients were divided into two groups based on pretreatment LDL-C levels: normal LDL-C (≤3.64 mmol/L; n=816) and elevated LDL-C (>3.64 mmol/L; n=119). Associations between pretreatment LDL-C levels and treatment outcome were analyzed by univariate and multivariate analyses. Results: The overall patient follow-up rate was 95.1%, and 726 patients received more than 5 years of follow-up. Five-year overall survival (OS), local control (LC), and distant metastasis-free survival (DMFS) rates of the entire patient population were 87.1%, 91.1%, and 87.2%, respectively. Rates of 5-year OS, LC, and DMFS for the elevated versus normal LDL-C groups were 77.0% vs 89.1% (P<0.001), 85.8% vs 91.9% (P=0.041), and 81.1% vs 88.1% (P=0.038), respectively. Compared with normal LDL-C levels, elevated LDL-C levels were identified as an independent prognostic factor of a poorer OS (hazard ratio [HR] =2.171; 95% confidence interval [CI] =1.424–3.309), LC rate (HR =1.762; 95% CI =1.021–3.942), and DMFS (HR =1.594; 95% CI =1.003–2.532). Conclusion: This study found that elevated pretreatment LDL-C levels are negative prognostic indicators of NPC. Elevated LDL-C levels may be useful indicators of locoregional control and distant metastasis in NPC patients. Keywords: LDL-cholesterol, nasopharyngeal carcinoma, prognosis |
topic |
LDL-cholesterol nasopharyngeal carcinoma prognosis |
url |
https://www.dovepress.com/correlation-between-pretreatment-serum-ldl-cholesterol-levels-and-prog-peer-reviewed-article-OTT |
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