Effect of anticonvulsants on the nitric oxide system

The effect of phenobarbital, carbamazepine, valproate sodium, depakine, topiramate and lamotrigine on the content of NO and NO-synthase activity in white rat brain tissues has been studied. It was established that the action of carbamazepine, valproate sodium, topiramate and lamotrigine decreases th...

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Main Authors:	L. A. Gromov, I. F. Belenichev, L. G. Gonchar-Cherdakli, G. A. Zhernovaja
Format:	Article
Language:	English
Published:	National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2013-02-01
Series:	Ukrainian Biochemical Journal
Subjects:	nitric oxide anticonvulsants NO-synthase
Online Access:	http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Gromov_1_13.pdf

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spelling	doaj-6dc44e393ebb4e35b6e7eb52dc9dca762020-11-24T22:20:46ZengNational Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.Ukrainian Biochemical Journal2409-49432413-50032013-02-01851798310.15407/ubj85.01.079Effect of anticonvulsants on the nitric oxide systemL. A. Gromov0I. F. Belenichev1L. G. Gonchar-Cherdakli2G. A. Zhernovaja3SI Іnstitute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine, KyivZaporizhia State Medical University, UkraineSI Іnstitute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine, KyivZaporizhia State Medical University, UkraineThe effect of phenobarbital, carbamazepine, valproate sodium, depakine, topiramate and lamotrigine on the content of NO and NO-synthase activity in white rat brain tissues has been studied. It was established that the action of carbamazepine, valproate sodium, topiramate and lamotrigine decreases the activity of NO-synthase and the level of NO in the brain tissues. The amount of NO does not change while NO-synthase activity increases with the introduction of phenobarbital. The involvement of nitric oxide in the mechanism of action of the studied anticonvulsant drugs is discussed.http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Gromov_1_13.pdfnitric oxideanticonvulsantsNO-synthase
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	L. A. Gromov I. F. Belenichev L. G. Gonchar-Cherdakli G. A. Zhernovaja
spellingShingle	L. A. Gromov I. F. Belenichev L. G. Gonchar-Cherdakli G. A. Zhernovaja Effect of anticonvulsants on the nitric oxide system Ukrainian Biochemical Journal nitric oxide anticonvulsants NO-synthase
author_facet	L. A. Gromov I. F. Belenichev L. G. Gonchar-Cherdakli G. A. Zhernovaja
author_sort	L. A. Gromov
title	Effect of anticonvulsants on the nitric oxide system
title_short	Effect of anticonvulsants on the nitric oxide system
title_full	Effect of anticonvulsants on the nitric oxide system
title_fullStr	Effect of anticonvulsants on the nitric oxide system
title_full_unstemmed	Effect of anticonvulsants on the nitric oxide system
title_sort	effect of anticonvulsants on the nitric oxide system
publisher	National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
series	Ukrainian Biochemical Journal
issn	2409-4943 2413-5003
publishDate	2013-02-01
description	The effect of phenobarbital, carbamazepine, valproate sodium, depakine, topiramate and lamotrigine on the content of NO and NO-synthase activity in white rat brain tissues has been studied. It was established that the action of carbamazepine, valproate sodium, topiramate and lamotrigine decreases the activity of NO-synthase and the level of NO in the brain tissues. The amount of NO does not change while NO-synthase activity increases with the introduction of phenobarbital. The involvement of nitric oxide in the mechanism of action of the studied anticonvulsant drugs is discussed.
topic	nitric oxide anticonvulsants NO-synthase
url	http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Gromov_1_13.pdf
work_keys_str_mv	AT lagromov effectofanticonvulsantsonthenitricoxidesystem AT ifbelenichev effectofanticonvulsantsonthenitricoxidesystem AT lggoncharcherdakli effectofanticonvulsantsonthenitricoxidesystem AT gazhernovaja effectofanticonvulsantsonthenitricoxidesystem
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Effect of anticonvulsants on the nitric oxide system

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