An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC pathway through up regulation of CCRK, resulting in he...
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Nature Publishing Group
2018-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07402-8 |
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doaj-6dd5d597aab145d5bf368e0227da0aaf2021-05-11T09:25:46ZengNature Publishing GroupNature Communications2041-17232018-12-019111610.1038/s41467-018-07402-8An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinomaHanyong Sun0Weiqin Yang1Yuan Tian2Xuezhen Zeng3Jingying Zhou4Myth T. S. Mok5Wenshu Tang6Yu Feng7Liangliang Xu8Anthony W. H. Chan9Joanna H. Tong10Yue-Sun Cheung11Paul B. S. Lai12Hector K. S. Wang13Shun-Wa Tsang14King-Lau Chow15Mengying Hu16Rihe Liu17Leaf Huang18Bing Yang19Pengyuan Yang20Ka-Fai To21Joseph J. Y. Sung22Grace L. H. Wong23Vincent W. S. Wong24Alfred S. L. Cheng25Department of Medicine and Therapeutics, The Chinese University of Hong KongSchool of Biomedical Sciences, The Chinese University of Hong KongDepartment of Medicine and Therapeutics, The Chinese University of Hong KongSchool of Biomedical Sciences, The Chinese University of Hong KongSchool of Biomedical Sciences, The Chinese University of Hong KongSchool of Biomedical Sciences, The Chinese University of Hong KongSchool of Biomedical Sciences, The Chinese University of Hong KongSchool of Biomedical Sciences, The Chinese University of Hong KongSchool of Biomedical Sciences, The Chinese University of Hong KongDepartment of Anatomical and Cellular Pathology, The Chinese University of Hong KongDepartment of Anatomical and Cellular Pathology, The Chinese University of Hong KongDepartment of Surgery, The Chinese University of Hong KongDepartment of Surgery, The Chinese University of Hong KongDivision of Life Science, The Hong Kong University of Science and TechnologyDivision of Life Science, The Hong Kong University of Science and TechnologyDivision of Life Science, The Hong Kong University of Science and TechnologyDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel HillDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy and Carolina Center for Genome Sciences, University of North Carolina at Chapel HillDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel HillKey Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of SciencesDepartment of Anatomical and Cellular Pathology, The Chinese University of Hong KongDepartment of Medicine and Therapeutics, The Chinese University of Hong KongDepartment of Medicine and Therapeutics, The Chinese University of Hong KongDepartment of Medicine and Therapeutics, The Chinese University of Hong KongSchool of Biomedical Sciences, The Chinese University of Hong KongObesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC pathway through up regulation of CCRK, resulting in hepatic steatosis worsening and HCC development via metabolic and immune reprogramming.https://doi.org/10.1038/s41467-018-07402-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hanyong Sun Weiqin Yang Yuan Tian Xuezhen Zeng Jingying Zhou Myth T. S. Mok Wenshu Tang Yu Feng Liangliang Xu Anthony W. H. Chan Joanna H. Tong Yue-Sun Cheung Paul B. S. Lai Hector K. S. Wang Shun-Wa Tsang King-Lau Chow Mengying Hu Rihe Liu Leaf Huang Bing Yang Pengyuan Yang Ka-Fai To Joseph J. Y. Sung Grace L. H. Wong Vincent W. S. Wong Alfred S. L. Cheng |
| spellingShingle |
Hanyong Sun Weiqin Yang Yuan Tian Xuezhen Zeng Jingying Zhou Myth T. S. Mok Wenshu Tang Yu Feng Liangliang Xu Anthony W. H. Chan Joanna H. Tong Yue-Sun Cheung Paul B. S. Lai Hector K. S. Wang Shun-Wa Tsang King-Lau Chow Mengying Hu Rihe Liu Leaf Huang Bing Yang Pengyuan Yang Ka-Fai To Joseph J. Y. Sung Grace L. H. Wong Vincent W. S. Wong Alfred S. L. Cheng An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma Nature Communications |
| author_facet |
Hanyong Sun Weiqin Yang Yuan Tian Xuezhen Zeng Jingying Zhou Myth T. S. Mok Wenshu Tang Yu Feng Liangliang Xu Anthony W. H. Chan Joanna H. Tong Yue-Sun Cheung Paul B. S. Lai Hector K. S. Wang Shun-Wa Tsang King-Lau Chow Mengying Hu Rihe Liu Leaf Huang Bing Yang Pengyuan Yang Ka-Fai To Joseph J. Y. Sung Grace L. H. Wong Vincent W. S. Wong Alfred S. L. Cheng |
| author_sort |
Hanyong Sun |
| title |
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma |
| title_short |
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma |
| title_full |
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma |
| title_fullStr |
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma |
| title_full_unstemmed |
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma |
| title_sort |
inflammatory-ccrk circuitry drives mtorc1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-12-01 |
| description |
Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC pathway through up regulation of CCRK, resulting in hepatic steatosis worsening and HCC development via metabolic and immune reprogramming. |
| url |
https://doi.org/10.1038/s41467-018-07402-8 |
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