Comparison of HCV viral load and its genotype distributions in HCV mono- and HIV/HCV co-infected illicit drug users
Abstract Background Because of shared modes of transmission, patients with hepatitis C virus (HCV) infection are often co-infected with other types of hepatitis viruses and/or HIV. We studied HCV viral load and its genotype patterns among HCV mono- and HCV/HIV co-infected Illicit Drug Users in Fars...
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doaj-6de1759e6cf04120b25d759659793b882020-11-25T00:47:36ZengBMCVirology Journal1743-422X2017-07-011411610.1186/s12985-017-0797-2Comparison of HCV viral load and its genotype distributions in HCV mono- and HIV/HCV co-infected illicit drug usersMarzieh Jamalidoust0Mandana Namayandeh1Mohsen Moghadami2Mazyar Ziyaeyan3Department of Virology, Professor Alborzi Clinical Microbiology Research Center, Nemazi Hospital, Shiraz University of Medical SciencesDepartment of Virology, Professor Alborzi Clinical Microbiology Research Center, Nemazi Hospital, Shiraz University of Medical SciencesDepartment of Virology, Professor Alborzi Clinical Microbiology Research Center, Nemazi hospital, Shiraz University of Medical SciencesDepartment of Virology, Professor Alborzi Clinical Microbiology Research Center, Nemazi Hospital, Shiraz University of Medical SciencesAbstract Background Because of shared modes of transmission, patients with hepatitis C virus (HCV) infection are often co-infected with other types of hepatitis viruses and/or HIV. We studied HCV viral load and its genotype patterns among HCV mono- and HCV/HIV co-infected Illicit Drug Users in Fars province-Iran. Methods Totally, 580 HCV seropositive IDUs referred to Prof. Alborzi Clinical Microbiology Research Center, Shiraz, Iran, without receiving any anti-HCV treatment, were enrolled. After their HCV infections were reconfirmed by one step rapid diagnostic test, HCV RNA level and HCV genotypes were determined by Taq-man real-time PCR assays. Their HIV serostatus was determined and seropositive patients were excluded from the group. In addition, 104 HIV/HCV co-infected IDUs referred from Shiraz Behavioral Diseases Consultation Center (SBDC) were assessed for HCV RNA level and HCV genotype patterns, as well. Results The overall estimated HIV prevalence was 6.7% (39/580) among HCV seropositive IDUs. Genotype 1, the most prevalent genotype in both groups, was detected in 69% and 49% of co- and mono-infected IDUs, respectively. Median HCV viral load was significantly higher in HIV/HCV co-infected patients, compared with that among HCV mono-infected counterparts. Conclusions Given the higher baseline HCV viral load and GT1 attributed to poorer treatments response, HCV treatment must be more considered among HCV/HIV co-infected IDUs, compared to those mono-infected with HCV.http://link.springer.com/article/10.1186/s12985-017-0797-2Hepatitis C virusHIVHCV genotypesIllicit drug usersQuantitative PCR assay |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marzieh Jamalidoust Mandana Namayandeh Mohsen Moghadami Mazyar Ziyaeyan |
spellingShingle |
Marzieh Jamalidoust Mandana Namayandeh Mohsen Moghadami Mazyar Ziyaeyan Comparison of HCV viral load and its genotype distributions in HCV mono- and HIV/HCV co-infected illicit drug users Virology Journal Hepatitis C virus HIV HCV genotypes Illicit drug users Quantitative PCR assay |
author_facet |
Marzieh Jamalidoust Mandana Namayandeh Mohsen Moghadami Mazyar Ziyaeyan |
author_sort |
Marzieh Jamalidoust |
title |
Comparison of HCV viral load and its genotype distributions in HCV mono- and HIV/HCV co-infected illicit drug users |
title_short |
Comparison of HCV viral load and its genotype distributions in HCV mono- and HIV/HCV co-infected illicit drug users |
title_full |
Comparison of HCV viral load and its genotype distributions in HCV mono- and HIV/HCV co-infected illicit drug users |
title_fullStr |
Comparison of HCV viral load and its genotype distributions in HCV mono- and HIV/HCV co-infected illicit drug users |
title_full_unstemmed |
Comparison of HCV viral load and its genotype distributions in HCV mono- and HIV/HCV co-infected illicit drug users |
title_sort |
comparison of hcv viral load and its genotype distributions in hcv mono- and hiv/hcv co-infected illicit drug users |
publisher |
BMC |
series |
Virology Journal |
issn |
1743-422X |
publishDate |
2017-07-01 |
description |
Abstract Background Because of shared modes of transmission, patients with hepatitis C virus (HCV) infection are often co-infected with other types of hepatitis viruses and/or HIV. We studied HCV viral load and its genotype patterns among HCV mono- and HCV/HIV co-infected Illicit Drug Users in Fars province-Iran. Methods Totally, 580 HCV seropositive IDUs referred to Prof. Alborzi Clinical Microbiology Research Center, Shiraz, Iran, without receiving any anti-HCV treatment, were enrolled. After their HCV infections were reconfirmed by one step rapid diagnostic test, HCV RNA level and HCV genotypes were determined by Taq-man real-time PCR assays. Their HIV serostatus was determined and seropositive patients were excluded from the group. In addition, 104 HIV/HCV co-infected IDUs referred from Shiraz Behavioral Diseases Consultation Center (SBDC) were assessed for HCV RNA level and HCV genotype patterns, as well. Results The overall estimated HIV prevalence was 6.7% (39/580) among HCV seropositive IDUs. Genotype 1, the most prevalent genotype in both groups, was detected in 69% and 49% of co- and mono-infected IDUs, respectively. Median HCV viral load was significantly higher in HIV/HCV co-infected patients, compared with that among HCV mono-infected counterparts. Conclusions Given the higher baseline HCV viral load and GT1 attributed to poorer treatments response, HCV treatment must be more considered among HCV/HIV co-infected IDUs, compared to those mono-infected with HCV. |
topic |
Hepatitis C virus HIV HCV genotypes Illicit drug users Quantitative PCR assay |
url |
http://link.springer.com/article/10.1186/s12985-017-0797-2 |
work_keys_str_mv |
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