Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis
Objective: To determine if there exists an upper limit for amount of blood transfused in trauma patients before it reaches a point of futility.Methods: A prospective cohort study was conducted on 131 patients who received massive blood transfusion (MBT), defined as 10 U or higher of PRBCs received i...
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Shiraz University of Medical Sciences
2018-07-01
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doaj-6de1f1dc1b5c493caa70de72760ddd272020-11-24T23:56:52ZengShiraz University of Medical SciencesBulletin of Emergency and Trauma2322-25222322-39602018-07-016Issue 321722044437Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat AnalysisSteven LiuQuinn FujiiFarris SerioAndrew McCagueObjective: To determine if there exists an upper limit for amount of blood transfused in trauma patients before it reaches a point of futility.Methods: A prospective cohort study was conducted on 131 patients who received massive blood transfusion (MBT), defined as 10 U or higher of PRBCs received in the initial 24 hours. Data collected from a Level II trauma center registry were used to analyze reports of adult patients from July 2014 to 2017. Cohorts were divided by amount of blood received - 0 to 9 U, 10-19 U, 20 to 29 U, 30-39 U, 40 U or higher - odds ratio for mortality and p-values for mean Injury Severity Score and overall hospital length of stay were calculated for each group.Results: Odds ratios for massive blood transfusion groups from 10 units to 39 units each contained the null value, while our 40 units and above group did not (OR 12.52, 95% CI 1.3-117.7).Conclusion: Although this study is limited by its sample size, these results suggests that 40 units of PRBCs may be a threshold at which survival rates begin to decrease significantly.http://beat.sums.ac.ir/article_44437_928bba90105fffeaaa676a9df49a1b48.pdfMassive transfusionBlood transfusionTraumaBlood loss |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Steven Liu Quinn Fujii Farris Serio Andrew McCague |
spellingShingle |
Steven Liu Quinn Fujii Farris Serio Andrew McCague Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis Bulletin of Emergency and Trauma Massive transfusion Blood transfusion Trauma Blood loss |
author_facet |
Steven Liu Quinn Fujii Farris Serio Andrew McCague |
author_sort |
Steven Liu |
title |
Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis |
title_short |
Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis |
title_full |
Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis |
title_fullStr |
Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis |
title_full_unstemmed |
Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis |
title_sort |
massive blood transfusions and outcomes in trauma patients; an intention to treat analysis |
publisher |
Shiraz University of Medical Sciences |
series |
Bulletin of Emergency and Trauma |
issn |
2322-2522 2322-3960 |
publishDate |
2018-07-01 |
description |
Objective: To determine if there exists an upper limit for amount of blood transfused in trauma patients before it reaches a point of futility.Methods: A prospective cohort study was conducted on 131 patients who received massive blood transfusion (MBT), defined as 10 U or higher of PRBCs received in the initial 24 hours. Data collected from a Level II trauma center registry were used to analyze reports of adult patients from July 2014 to 2017. Cohorts were divided by amount of blood received - 0 to 9 U, 10-19 U, 20 to 29 U, 30-39 U, 40 U or higher - odds ratio for mortality and p-values for mean Injury Severity Score and overall hospital length of stay were calculated for each group.Results: Odds ratios for massive blood transfusion groups from 10 units to 39 units each contained the null value, while our 40 units and above group did not (OR 12.52, 95% CI 1.3-117.7).Conclusion: Although this study is limited by its sample size, these results suggests that 40 units of PRBCs may be a threshold at which survival rates begin to decrease significantly. |
topic |
Massive transfusion Blood transfusion Trauma Blood loss |
url |
http://beat.sums.ac.ir/article_44437_928bba90105fffeaaa676a9df49a1b48.pdf |
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