Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways

Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways

Pattern recognition receptors (PRRs) form the front line of defense against pathogens. Many of the molecular mechanisms that facilitate PRR signaling have been characterized in detail, which is critical for the development of accurate PRR pathway models at the molecular interaction level.

Bibliographic Details
Main Authors: Nathan P. Manes, Aleksandra Nita-Lazar
Format: Article
Language:English
Published: American Society for Microbiology 2021-06-01
Series:mSystems
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00336-21
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spelling doaj-6de57a808ac44dc58d7511e3293f15562021-09-21T18:52:40ZengAmerican Society for MicrobiologymSystems2379-50772021-06-016310.1128/mSystems.00336-21Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon PathwaysNathan P. Manes0https://orcid.org/0000-0001-6701-3314Aleksandra Nita-Lazar1https://orcid.org/0000-0002-8523-605XFunctional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USAFunctional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Pattern recognition receptors (PRRs) form the front line of defense against pathogens. Many of the molecular mechanisms that facilitate PRR signaling have been characterized in detail, which is critical for the development of accurate PRR pathway models at the molecular interaction level.https://journals.asm.org/doi/10.1128/mSystems.00336-21
collection DOAJ
language English
format Article
sources DOAJ
author Nathan P. Manes
Aleksandra Nita-Lazar
spellingShingle Nathan P. Manes
Aleksandra Nita-Lazar
Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
mSystems
author_facet Nathan P. Manes
Aleksandra Nita-Lazar
author_sort Nathan P. Manes
title Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
title_short Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
title_full Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
title_fullStr Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
title_full_unstemmed Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
title_sort molecular mechanisms of the toll-like receptor, sting, mavs, inflammasome, and interferon pathways
publisher American Society for Microbiology
series mSystems
issn 2379-5077
publishDate 2021-06-01
description Pattern recognition receptors (PRRs) form the front line of defense against pathogens. Many of the molecular mechanisms that facilitate PRR signaling have been characterized in detail, which is critical for the development of accurate PRR pathway models at the molecular interaction level.
url https://journals.asm.org/doi/10.1128/mSystems.00336-21
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AT aleksandranitalazar molecularmechanismsofthetolllikereceptorstingmavsinflammasomeandinterferonpathways
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