Principles of the treatment of chronic Epstein–Barr virus infection and associated diseases
Epstein – Barr virus, related to herpes viruses, causes infectious mononucleosis during the initial infection; after recovery, the virus persists in the body throughout lifetime. The presence of clinical symptoms and viral load in a patient in 6 months after the infectious mononucleosis disease indi...
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Ltd. “The National Academy of Pediatric Science and Innovation”
2019-05-01
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Online Access: | https://www.ped-perinatology.ru/jour/article/view/854 |
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doaj-6de9161d10a44288ad907f237a64e7e52021-07-28T16:27:50ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282019-05-01642384610.21508/1027-4065-2019-64-2-38-46715Principles of the treatment of chronic Epstein–Barr virus infection and associated diseasesS. A. Yakushyna0L. B. Kisteneva1S. G. Cheshyk2Gamaleya National Research Centre of Epidemiology and MicrobiologyGamaleya National Research Centre of Epidemiology and MicrobiologyGamaleya National Research Centre of Epidemiology and MicrobiologyEpstein – Barr virus, related to herpes viruses, causes infectious mononucleosis during the initial infection; after recovery, the virus persists in the body throughout lifetime. The presence of clinical symptoms and viral load in a patient in 6 months after the infectious mononucleosis disease indicates the formation of chronic active Epstein – Barr viral infection. Hemophagocytic lymphohistiocytosis, posttransplantation lymphoproliferative disease and chronic fatigue syndrome, which has a polyetiological nature, are also associated with the activation of the persistent Epstein – Barr virus. Most of these diseases develop in children due to their physiological immunodeficiency and are accompanied by high mortality – up to 50%. Immune mechanisms, in addition to the virus itself, play a leading role in the pathogenesis of the diseases. The article summarizes all existing approaches to the treatment of chronic Epstein – Barr virus-associated diseases. The authors have analyzed the effectiveness of these approaches on the basis of various published studies. These diseases are treated with etiotropic antiviral drugs – nucleoside analogs, nonspecific immunotherapy, targeted therapy with monoclonal antibody preparations, immune cellular CD8+ therapy. In case of ineffectiveness of these methods, the alternative bone marrow transplantation is used. The article highlightes promising areas for the development of new approaches to the treatment of Epstein – Barr virus-associated diseases.https://www.ped-perinatology.ru/jour/article/view/854childrenepstein–barr viruschronic active epstein–barr viral infectionhemophagocytic lymphohistiocytosisposttransplantation lymphoproliferative diseasetreatmenttarget therapy |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
S. A. Yakushyna L. B. Kisteneva S. G. Cheshyk |
spellingShingle |
S. A. Yakushyna L. B. Kisteneva S. G. Cheshyk Principles of the treatment of chronic Epstein–Barr virus infection and associated diseases Rossijskij Vestnik Perinatologii i Pediatrii children epstein–barr virus chronic active epstein–barr viral infection hemophagocytic lymphohistiocytosis posttransplantation lymphoproliferative disease treatment target therapy |
author_facet |
S. A. Yakushyna L. B. Kisteneva S. G. Cheshyk |
author_sort |
S. A. Yakushyna |
title |
Principles of the treatment of chronic Epstein–Barr virus infection and associated diseases |
title_short |
Principles of the treatment of chronic Epstein–Barr virus infection and associated diseases |
title_full |
Principles of the treatment of chronic Epstein–Barr virus infection and associated diseases |
title_fullStr |
Principles of the treatment of chronic Epstein–Barr virus infection and associated diseases |
title_full_unstemmed |
Principles of the treatment of chronic Epstein–Barr virus infection and associated diseases |
title_sort |
principles of the treatment of chronic epstein–barr virus infection and associated diseases |
publisher |
Ltd. “The National Academy of Pediatric Science and Innovation” |
series |
Rossijskij Vestnik Perinatologii i Pediatrii |
issn |
1027-4065 2500-2228 |
publishDate |
2019-05-01 |
description |
Epstein – Barr virus, related to herpes viruses, causes infectious mononucleosis during the initial infection; after recovery, the virus persists in the body throughout lifetime. The presence of clinical symptoms and viral load in a patient in 6 months after the infectious mononucleosis disease indicates the formation of chronic active Epstein – Barr viral infection. Hemophagocytic lymphohistiocytosis, posttransplantation lymphoproliferative disease and chronic fatigue syndrome, which has a polyetiological nature, are also associated with the activation of the persistent Epstein – Barr virus. Most of these diseases develop in children due to their physiological immunodeficiency and are accompanied by high mortality – up to 50%. Immune mechanisms, in addition to the virus itself, play a leading role in the pathogenesis of the diseases. The article summarizes all existing approaches to the treatment of chronic Epstein – Barr virus-associated diseases. The authors have analyzed the effectiveness of these approaches on the basis of various published studies. These diseases are treated with etiotropic antiviral drugs – nucleoside analogs, nonspecific immunotherapy, targeted therapy with monoclonal antibody preparations, immune cellular CD8+ therapy. In case of ineffectiveness of these methods, the alternative bone marrow transplantation is used. The article highlightes promising areas for the development of new approaches to the treatment of Epstein – Barr virus-associated diseases. |
topic |
children epstein–barr virus chronic active epstein–barr viral infection hemophagocytic lymphohistiocytosis posttransplantation lymphoproliferative disease treatment target therapy |
url |
https://www.ped-perinatology.ru/jour/article/view/854 |
work_keys_str_mv |
AT sayakushyna principlesofthetreatmentofchronicepsteinbarrvirusinfectionandassociateddiseases AT lbkisteneva principlesofthetreatmentofchronicepsteinbarrvirusinfectionandassociateddiseases AT sgcheshyk principlesofthetreatmentofchronicepsteinbarrvirusinfectionandassociateddiseases |
_version_ |
1721266192516120576 |