Computational optimization of angiotensin-converting enzyme 2 for SARS-CoV-2 Spike molecular recognition

Computational optimization of angiotensin-converting enzyme 2 for SARS-CoV-2 Spike molecular recognition

Since the beginning of the Covid19 pandemic, many efforts have been devoted to identifying approaches to neutralize SARS-CoV-2 replication within the host cell. A promising strategy to block the infection consists of using a mutant of the human receptor angiotensin-converting enzyme 2 (ACE2) as a de...

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Bibliographic Details
Main Authors: Lorenzo Di Rienzo, Michele Monti, Edoardo Milanetti, Mattia Miotto, Alberto Boffi, Gian Gaetano Tartaglia, Giancarlo Ruocco
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Molecular design
SARS-CoV-2
ACE2-Spike interaction
Molecular recognition
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021001975

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