Mechanisms and targets of Fcγ-receptor mediated immunity to malaria sporozoites
Antibodies plays critical roles in the adaptive immune response to infectious agents including malaria. Here the authors defined antibody interactions with -Fcγ-receptors expressed on immune cells with sporozoites of Plasmodium falciparum, and identified specific target epitopes of antibodies.
Main Authors: | Gaoqian Feng, Bruce D. Wines, Liriye Kurtovic, Jo-Anne Chan, Philippe Boeuf, Vanessa Mollard, Anton Cozijnsen, Damien R. Drew, Rob J. Center, Daniel L. Marshall, Sandra Chishimba, Geoffrey I. McFadden, Arlene E. Dent, Kiprotich Chelimo, Michelle J. Boyle, James W. Kazura, P. Mark Hogarth, James G. Beeson |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-03-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-21998-4 |
Similar Items
-
Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children
by: Liriye Kurtovic, et al.
Published: (2018-04-01) -
The Human FcγRII (CD32) Family of Leukocyte FcR in Health and Disease
by: Jessica C. Anania, et al.
Published: (2019-03-01) -
Novel Virus-Like Particle Vaccine Encoding the Circumsporozoite Protein of Plasmodium falciparum Is Immunogenic and Induces Functional Antibody Responses in Mice
by: Liriye Kurtovic, et al.
Published: (2021-03-01) -
Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria
by: Jo-Anne Chan, et al.
Published: (2019-01-01) -
Epitope Mapping of Fc gamma RIIa Monoclonal Antibodies
by: Caroline Tan Sardjono, et al.
Published: (2008-06-01)