Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis

Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis

Hyperpolarization-activated cyclic-nucleotide gated channel (HCN) proteins are important regulators of both neuronal and cardiac excitability. Among the 4 HCN isoforms, HCN4 is known as a pacemaker channel, because it helps control the periodicity of contractions in vertebrate hearts. Although the p...

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Bibliographic Details
Main Authors: Emily Pitcairn, Hannah Harris, Justine Epiney, Vaibhav P. Pai, Joan M. Lemire, Bin Ye, Nian-Qing Shi, Michael Levin, Kelly A. McLaughlin
Format: Article
Language:English
Published: Taylor & Francis Group 2017-05-01
Series:Communicative & Integrative Biology
Subjects:
bioelectricity
cardiogenesis
HCN4
ion channel
membrane potential
morphogenesis
positional identity
Online Access:http://dx.doi.org/10.1080/19420889.2017.1309488

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