Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions
Skeletal muscle stem cells (or satellite cells, SCs) are normally quiescent but activate and expand in response to injury. Here the authors show that induction of DHX36 helicase during SC activation promotes mRNA translation by binding to 5′UTR mRNA G-quadruplexes (rG4) in targets including Gnai2 an...
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Nature Publishing Group
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25170-w |
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doaj-6dfdbd5e24c94a98ae8d2a286fba0f682021-08-22T11:40:10ZengNature Publishing GroupNature Communications2041-17232021-08-0112112210.1038/s41467-021-25170-wTranslational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functionsXiaona Chen0Jie Yuan1Guang Xue2Silvia Campanario3Di Wang4Wen Wang5Xi Mou6Shiau Wei Liew7Mubarak Ishaq Umar8Joan Isern9Yu Zhao10Liangqiang He11Yuying Li12Christopher J. Mann13Xiaohua Yu14Lei Wang15Eusebio Perdiguero16Wei Chen17Yuanchao Xue18Yoshikuni Nagamine19Chun Kit Kwok20Hao Sun21Pura Muñoz-Cánoves22Huating Wang23Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong KongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong KongDepartment of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong KongDepartment of Experimental & Health Sciences, Universitat Pompeu Fabra (UPF), CIBERNED, ICREAKey Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of SciencesDepartment of Biology, Southern University of Science and TechnologyDepartment of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon TongDepartment of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon TongDepartment of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon TongDepartment of Experimental & Health Sciences, Universitat Pompeu Fabra (UPF), CIBERNED, ICREADepartment of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong KongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong KongDepartment of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong KongDepartment of Experimental & Health Sciences, Universitat Pompeu Fabra (UPF), CIBERNED, ICREAKey Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of SciencesDepartment of Experimental & Health Sciences, Universitat Pompeu Fabra (UPF), CIBERNED, ICREADepartment of Biology, Southern University of Science and TechnologyKey Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of SciencesFriedrich Miescher Institute for Biomedical Research, Novartis Research FoundationDepartment of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon TongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong KongDepartment of Experimental & Health Sciences, Universitat Pompeu Fabra (UPF), CIBERNED, ICREADepartment of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong KongSkeletal muscle stem cells (or satellite cells, SCs) are normally quiescent but activate and expand in response to injury. Here the authors show that induction of DHX36 helicase during SC activation promotes mRNA translation by binding to 5′UTR mRNA G-quadruplexes (rG4) in targets including Gnai2 and unwinding them.https://doi.org/10.1038/s41467-021-25170-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xiaona Chen Jie Yuan Guang Xue Silvia Campanario Di Wang Wen Wang Xi Mou Shiau Wei Liew Mubarak Ishaq Umar Joan Isern Yu Zhao Liangqiang He Yuying Li Christopher J. Mann Xiaohua Yu Lei Wang Eusebio Perdiguero Wei Chen Yuanchao Xue Yoshikuni Nagamine Chun Kit Kwok Hao Sun Pura Muñoz-Cánoves Huating Wang |
| spellingShingle |
Xiaona Chen Jie Yuan Guang Xue Silvia Campanario Di Wang Wen Wang Xi Mou Shiau Wei Liew Mubarak Ishaq Umar Joan Isern Yu Zhao Liangqiang He Yuying Li Christopher J. Mann Xiaohua Yu Lei Wang Eusebio Perdiguero Wei Chen Yuanchao Xue Yoshikuni Nagamine Chun Kit Kwok Hao Sun Pura Muñoz-Cánoves Huating Wang Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions Nature Communications |
| author_facet |
Xiaona Chen Jie Yuan Guang Xue Silvia Campanario Di Wang Wen Wang Xi Mou Shiau Wei Liew Mubarak Ishaq Umar Joan Isern Yu Zhao Liangqiang He Yuying Li Christopher J. Mann Xiaohua Yu Lei Wang Eusebio Perdiguero Wei Chen Yuanchao Xue Yoshikuni Nagamine Chun Kit Kwok Hao Sun Pura Muñoz-Cánoves Huating Wang |
| author_sort |
Xiaona Chen |
| title |
Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions |
| title_short |
Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions |
| title_full |
Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions |
| title_fullStr |
Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions |
| title_full_unstemmed |
Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions |
| title_sort |
translational control by dhx36 binding to 5′utr g-quadruplex is essential for muscle stem-cell regenerative functions |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-08-01 |
| description |
Skeletal muscle stem cells (or satellite cells, SCs) are normally quiescent but activate and expand in response to injury. Here the authors show that induction of DHX36 helicase during SC activation promotes mRNA translation by binding to 5′UTR mRNA G-quadruplexes (rG4) in targets including Gnai2 and unwinding them. |
| url |
https://doi.org/10.1038/s41467-021-25170-w |
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