Adiposity and Serum Selenium in U.S. Adults
Requirements for selenium and other antioxidant nutrients are increased in pro-oxidant and pro-inflammatory conditions such as excess adiposity. Data concerning the association of excess general and central adiposity with circulating selenium concentrations, however, are limited. We examined the cro...
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doaj-6e0330a3d73641f7ab1224a5d722b6cb2020-11-25T01:05:58ZengMDPI AGNutrients2072-66432018-06-0110672710.3390/nu10060727nu10060727Adiposity and Serum Selenium in U.S. AdultsQiuan Zhong0Ruoxi Lin1Qingjiao Nong2Guangxi Medical University, School of Public Health, Department of Epidemiology, Nanning 530021, ChinaJohns Hopkins Bloomberg School of Public Health, Departments of Epidemiology and Welch Center for Prevention Epidemiology and Clinical Research, Baltimore, MD 21205, USAGuangxi Medical University, School of Public Health, Department of Epidemiology, Nanning 530021, ChinaRequirements for selenium and other antioxidant nutrients are increased in pro-oxidant and pro-inflammatory conditions such as excess adiposity. Data concerning the association of excess general and central adiposity with circulating selenium concentrations, however, are limited. We examined the cross-sectional associations of body mass index (BMI), percent body fat (%BF), and waist circumference (WC) with serum selenium concentrations in 6440 men and 6849 women aged ≥20 years who participated in the U.S. Third National Health and Nutrition Examination Survey. In multivariable analyses, the average difference (95% confidence interval (CI)) in serum selenium comparing the highest with the lowest quartiles of BMI was −4.0 (−5.5, −1.6) ng/mL in both men and women. These inverse associations were evident after further adjustment for WC. For %BF, the average differences (95% CI) in serum selenium between the highest and the lowest quartiles of %BF were −1.7 (−4.2, 0.7) ng/mL in men and −4.5 (−7.0, −1.9) ng/mL in women. The inverse association in women persisted after adjusting for WC. For WC, the average differences (95% CI) in serum selenium between the highest and the lowest quartiles were −1.9 (−3.8, −0.1) ng/mL in men and −3.9 (−5.8, −2.0) ng/mL in women. After further adjustment for BMI, the inverse association became positive in men and null in women. Our findings suggest that general and central adiposity have different associations with serum selenium levels and that these associations may depend on gender.http://www.mdpi.com/2072-6643/10/6/727adipositybody mass indexpercent body fatwaist circumferenceselenium |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qiuan Zhong Ruoxi Lin Qingjiao Nong |
spellingShingle |
Qiuan Zhong Ruoxi Lin Qingjiao Nong Adiposity and Serum Selenium in U.S. Adults Nutrients adiposity body mass index percent body fat waist circumference selenium |
author_facet |
Qiuan Zhong Ruoxi Lin Qingjiao Nong |
author_sort |
Qiuan Zhong |
title |
Adiposity and Serum Selenium in U.S. Adults |
title_short |
Adiposity and Serum Selenium in U.S. Adults |
title_full |
Adiposity and Serum Selenium in U.S. Adults |
title_fullStr |
Adiposity and Serum Selenium in U.S. Adults |
title_full_unstemmed |
Adiposity and Serum Selenium in U.S. Adults |
title_sort |
adiposity and serum selenium in u.s. adults |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-06-01 |
description |
Requirements for selenium and other antioxidant nutrients are increased in pro-oxidant and pro-inflammatory conditions such as excess adiposity. Data concerning the association of excess general and central adiposity with circulating selenium concentrations, however, are limited. We examined the cross-sectional associations of body mass index (BMI), percent body fat (%BF), and waist circumference (WC) with serum selenium concentrations in 6440 men and 6849 women aged ≥20 years who participated in the U.S. Third National Health and Nutrition Examination Survey. In multivariable analyses, the average difference (95% confidence interval (CI)) in serum selenium comparing the highest with the lowest quartiles of BMI was −4.0 (−5.5, −1.6) ng/mL in both men and women. These inverse associations were evident after further adjustment for WC. For %BF, the average differences (95% CI) in serum selenium between the highest and the lowest quartiles of %BF were −1.7 (−4.2, 0.7) ng/mL in men and −4.5 (−7.0, −1.9) ng/mL in women. The inverse association in women persisted after adjusting for WC. For WC, the average differences (95% CI) in serum selenium between the highest and the lowest quartiles were −1.9 (−3.8, −0.1) ng/mL in men and −3.9 (−5.8, −2.0) ng/mL in women. After further adjustment for BMI, the inverse association became positive in men and null in women. Our findings suggest that general and central adiposity have different associations with serum selenium levels and that these associations may depend on gender. |
topic |
adiposity body mass index percent body fat waist circumference selenium |
url |
http://www.mdpi.com/2072-6643/10/6/727 |
work_keys_str_mv |
AT qiuanzhong adiposityandserumseleniuminusadults AT ruoxilin adiposityandserumseleniuminusadults AT qingjiaonong adiposityandserumseleniuminusadults |
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