This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols

This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols

Abstract Background There are limited research and literature on the trial management challenges encountered in running adaptive platform trials. This trial design allows both (1) the seamless addition of new research comparisons when compelling clinical and scientific research questions emerge, and...

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Main Authors: Francesca Schiavone, Riya Bathia, Krishna Letchemanan, Lindsey Masters, Claire Amos, Anna Bara, Louise Brown, Clare Gilson, Cheryl Pugh, Nafisah Atako, Fleur Hudson, Mahesh Parmar, Ruth Langley, Richard S. Kaplan, Chris Parker, Gert Attard, Noel W. Clarke, Silke Gillessen, Nicholas D. James, Tim Maughan, Matthew R. Sydes, On behalf of past and present members of the STAMPEDE and FOCUS4 Trial Management Group
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Trials
Subjects:
Adaptive trials
Platform
Multi-arm multi stage
Protocol
Trial conduct
Trial management
Online Access:http://link.springer.com/article/10.1186/s13063-019-3216-8

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