Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model

Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model

Abstract Background Calcific aortic valve disease (CAVD) pathophysiology is a complex, multistage process, usually diagnosed at advanced stages after significant anatomical and hemodynamic changes in the valve. Early detection of disease progression is thus pivotal in the development of prevention a...

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Bibliographic Details
Main Authors: Ishita Tandon, Shelby Johns, Alan Woessner, Jessica Perez, Delaney Cross, Asya Ozkizilcik, Timothy J. Muldoon, Srikanth Vallurupalli, Muralidhar Padala, Kyle P. Quinn, Kartik Balachandran
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Cardiovascular Disorders
Subjects:
Calcific aortic valve disease
Valve calcification
Two-photon excited fluorescence microscopy
Wild-type mouse model
Online Access:https://doi.org/10.1186/s12872-020-01776-8

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