Paying the Toll in Nuclear Reprogramming

The ability to reverse lineage-committed cells toward pluripotent stem cells or to another cell type is one of the ultimate goals in regenerative medicine. We recently discovered that activation of innate immunity, through Toll-like receptor 3, is required during this conversion of cell fate by caus...

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Main Authors:	Chun Liu, Farhan Himmati, Nazish Sayed
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-08-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	nuclear reprogramming human induced pluripotent stem cells transdifferentiation innate immunity toll-like receptors
Online Access:	http://journal.frontiersin.org/article/10.3389/fcell.2017.00070/full

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spelling	doaj-6e0e2caf6ba6492284112d7c30ead0ba2020-11-25T00:04:03ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2017-08-01510.3389/fcell.2017.00070277756Paying the Toll in Nuclear ReprogrammingChun Liu0Chun Liu1Farhan Himmati2Nazish Sayed3Nazish Sayed4Stanford Cardiovascular Institute, Stanford University School of MedicineStanford, CA, United StatesDepartment of Medicine, Stanford University School of MedicineStanford, CA, United StatesStanford Cardiovascular Institute, Stanford University School of MedicineStanford, CA, United StatesStanford Cardiovascular Institute, Stanford University School of MedicineStanford, CA, United StatesDepartment of Medicine, Stanford University School of MedicineStanford, CA, United StatesThe ability to reverse lineage-committed cells toward pluripotent stem cells or to another cell type is one of the ultimate goals in regenerative medicine. We recently discovered that activation of innate immunity, through Toll-like receptor 3, is required during this conversion of cell fate by causing global changes in the expression and activity of epigenetic modifiers. Here we discuss, in a comprehensive manner, the recent studies on the role of innate immunity in nuclear reprogramming and transdifferentiation, the underlying mechanisms, and its role in regenerative medicine.http://journal.frontiersin.org/article/10.3389/fcell.2017.00070/fullnuclear reprogramminghuman induced pluripotent stem cellstransdifferentiationinnate immunitytoll-like receptors
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chun Liu Chun Liu Farhan Himmati Nazish Sayed Nazish Sayed
spellingShingle	Chun Liu Chun Liu Farhan Himmati Nazish Sayed Nazish Sayed Paying the Toll in Nuclear Reprogramming Frontiers in Cell and Developmental Biology nuclear reprogramming human induced pluripotent stem cells transdifferentiation innate immunity toll-like receptors
author_facet	Chun Liu Chun Liu Farhan Himmati Nazish Sayed Nazish Sayed
author_sort	Chun Liu
title	Paying the Toll in Nuclear Reprogramming
title_short	Paying the Toll in Nuclear Reprogramming
title_full	Paying the Toll in Nuclear Reprogramming
title_fullStr	Paying the Toll in Nuclear Reprogramming
title_full_unstemmed	Paying the Toll in Nuclear Reprogramming
title_sort	paying the toll in nuclear reprogramming
publisher	Frontiers Media S.A.
series	Frontiers in Cell and Developmental Biology
issn	2296-634X
publishDate	2017-08-01
description	The ability to reverse lineage-committed cells toward pluripotent stem cells or to another cell type is one of the ultimate goals in regenerative medicine. We recently discovered that activation of innate immunity, through Toll-like receptor 3, is required during this conversion of cell fate by causing global changes in the expression and activity of epigenetic modifiers. Here we discuss, in a comprehensive manner, the recent studies on the role of innate immunity in nuclear reprogramming and transdifferentiation, the underlying mechanisms, and its role in regenerative medicine.
topic	nuclear reprogramming human induced pluripotent stem cells transdifferentiation innate immunity toll-like receptors
url	http://journal.frontiersin.org/article/10.3389/fcell.2017.00070/full
work_keys_str_mv	AT chunliu payingthetollinnuclearreprogramming AT chunliu payingthetollinnuclearreprogramming AT farhanhimmati payingthetollinnuclearreprogramming AT nazishsayed payingthetollinnuclearreprogramming AT nazishsayed payingthetollinnuclearreprogramming
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Paying the Toll in Nuclear Reprogramming

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