Therapeutic administration of recombinant Paracoccin confers protection against paracoccidioides brasiliensis infection: involvement of TLRs.

Therapeutic administration of recombinant Paracoccin confers protection against paracoccidioides brasiliensis infection: involvement of TLRs.

Paracoccin (PCN) is an N-acetylglucosamine-binding lectin from the human pathogenic fungus Paracoccidioides brasiliensis. Recombinant PCN (rPCN) induces a T helper (Th) 1 immune response when prophylactically administered to BALB/c mice, protecting them against subsequent challenge with P. brasilien...

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Bibliographic Details
Main Authors: Ana Claudia Paiva Alegre-Maller, Flávia Costa Mendonça, Thiago Aparecido da Silva, Aline Ferreira Oliveira, Mateus Silveira Freitas, Ebert Seixas Hanna, Igor C Almeida, Nicholas J Gay, Maria Cristina Roque-Barreira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-12-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4256291?pdf=render

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http://europepmc.org/articles/PMC4256291?pdf=render

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