TAZ Is Related to Postoperative In-Hospital Mortality of Acute Type A Aortic Dissection
Background: Surgical repair of acute type A aortic dissection (ATAAD) has high risk and mortality, and there are few biomarkers of postoperative in-hospital mortality until now. This study investigated the association between WW domain–containing transcription regulator protein 1 (TAZ) and the posto...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-11-01
|
Series: | Frontiers in Cardiovascular Medicine |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2020.587996/full |
id |
doaj-6e1c9044d0d24e1abf6b0658fce2d5d2 |
---|---|
record_format |
Article |
spelling |
doaj-6e1c9044d0d24e1abf6b0658fce2d5d22020-11-25T03:41:03ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2020-11-01710.3389/fcvm.2020.587996587996TAZ Is Related to Postoperative In-Hospital Mortality of Acute Type A Aortic DissectionWenjian Jiang0Wenjian Jiang1Wenjian Jiang2Yuan Xue3Yuan Xue4Yuan Xue5Haibin Li6Hongjia Zhang7Hongjia Zhang8Hongjia Zhang9Yuanfei Zhao10Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaBeijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, ChinaBeijing Lab for Cardiovascular Precision Medicine, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaBeijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, ChinaBeijing Lab for Cardiovascular Precision Medicine, Beijing, ChinaBeijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaBeijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, ChinaBeijing Lab for Cardiovascular Precision Medicine, Beijing, ChinaCentre for Transplant and Renal Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, AustraliaBackground: Surgical repair of acute type A aortic dissection (ATAAD) has high risk and mortality, and there are few biomarkers of postoperative in-hospital mortality until now. This study investigated the association between WW domain–containing transcription regulator protein 1 (TAZ) and the postoperative in-hospital mortality of ATAAD patients.Methods: This is a retrospective cohort study. Data and blood samples were collected from 95 consecutive patients with ATAAD who underwent surgeries in our hospital from July 1, 2016, to December 31, 2016. The data collection included all the risk factors introduced by the modified EuroSCORE (European System for Cardiac Operative Risk Evaluation). The predictors of postoperative in-hospital death were confirmed by univariate regression analysis. Multivariable logistic regressions were used to analyze the association of the preoperative plasma level of TAZ and the postoperative in-hospital mortality of ATAAD patients. In addition, we used the generalized additive model to identify non-linear relationships.Results: Three models were used in the multivariable logistic regression analysis of the relationship between the preoperative plasma level of TAZ and postoperative in-hospital death. In the crude model, the preoperative plasma level of TAZ showed a positive correlation with postoperative in-hospital death [odds ratio (OR) = 1.33, 95% confidence interval (CI): 1.01–1.74, P = 0.04]. In adjusted model I and adjusted model II, similar results were found (OR = 1.35, 95% CI: 1.01–1.80, P = 0.04 and OR = 1.35, 95% CI: 1.01–1.81, P = 0.04). The risk of postoperative in-hospital death in the preoperative plasma level of the TAZ≥12.70 ng/mL group was 10.08 times (OR = 10.08, 95% CI: 1.63–62.37; P = 0.01) that of the preoperative plasma level of the TAZ <12.70 ng/mL group.Conclusions: The high preoperative plasma level of TAZ suggested poor surgical prognosis for ATAAD patients. The patients with a preoperative plasma level of TAZ ≥ 12.7 ng/ml had much higher postoperative in-hospital mortality.https://www.frontiersin.org/articles/10.3389/fcvm.2020.587996/fullaortic dissectionheart surgerymortalityascending aorta and total aortic arch replacementTAZ |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenjian Jiang Wenjian Jiang Wenjian Jiang Yuan Xue Yuan Xue Yuan Xue Haibin Li Hongjia Zhang Hongjia Zhang Hongjia Zhang Yuanfei Zhao |
spellingShingle |
Wenjian Jiang Wenjian Jiang Wenjian Jiang Yuan Xue Yuan Xue Yuan Xue Haibin Li Hongjia Zhang Hongjia Zhang Hongjia Zhang Yuanfei Zhao TAZ Is Related to Postoperative In-Hospital Mortality of Acute Type A Aortic Dissection Frontiers in Cardiovascular Medicine aortic dissection heart surgery mortality ascending aorta and total aortic arch replacement TAZ |
author_facet |
Wenjian Jiang Wenjian Jiang Wenjian Jiang Yuan Xue Yuan Xue Yuan Xue Haibin Li Hongjia Zhang Hongjia Zhang Hongjia Zhang Yuanfei Zhao |
author_sort |
Wenjian Jiang |
title |
TAZ Is Related to Postoperative In-Hospital Mortality of Acute Type A Aortic Dissection |
title_short |
TAZ Is Related to Postoperative In-Hospital Mortality of Acute Type A Aortic Dissection |
title_full |
TAZ Is Related to Postoperative In-Hospital Mortality of Acute Type A Aortic Dissection |
title_fullStr |
TAZ Is Related to Postoperative In-Hospital Mortality of Acute Type A Aortic Dissection |
title_full_unstemmed |
TAZ Is Related to Postoperative In-Hospital Mortality of Acute Type A Aortic Dissection |
title_sort |
taz is related to postoperative in-hospital mortality of acute type a aortic dissection |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2020-11-01 |
description |
Background: Surgical repair of acute type A aortic dissection (ATAAD) has high risk and mortality, and there are few biomarkers of postoperative in-hospital mortality until now. This study investigated the association between WW domain–containing transcription regulator protein 1 (TAZ) and the postoperative in-hospital mortality of ATAAD patients.Methods: This is a retrospective cohort study. Data and blood samples were collected from 95 consecutive patients with ATAAD who underwent surgeries in our hospital from July 1, 2016, to December 31, 2016. The data collection included all the risk factors introduced by the modified EuroSCORE (European System for Cardiac Operative Risk Evaluation). The predictors of postoperative in-hospital death were confirmed by univariate regression analysis. Multivariable logistic regressions were used to analyze the association of the preoperative plasma level of TAZ and the postoperative in-hospital mortality of ATAAD patients. In addition, we used the generalized additive model to identify non-linear relationships.Results: Three models were used in the multivariable logistic regression analysis of the relationship between the preoperative plasma level of TAZ and postoperative in-hospital death. In the crude model, the preoperative plasma level of TAZ showed a positive correlation with postoperative in-hospital death [odds ratio (OR) = 1.33, 95% confidence interval (CI): 1.01–1.74, P = 0.04]. In adjusted model I and adjusted model II, similar results were found (OR = 1.35, 95% CI: 1.01–1.80, P = 0.04 and OR = 1.35, 95% CI: 1.01–1.81, P = 0.04). The risk of postoperative in-hospital death in the preoperative plasma level of the TAZ≥12.70 ng/mL group was 10.08 times (OR = 10.08, 95% CI: 1.63–62.37; P = 0.01) that of the preoperative plasma level of the TAZ <12.70 ng/mL group.Conclusions: The high preoperative plasma level of TAZ suggested poor surgical prognosis for ATAAD patients. The patients with a preoperative plasma level of TAZ ≥ 12.7 ng/ml had much higher postoperative in-hospital mortality. |
topic |
aortic dissection heart surgery mortality ascending aorta and total aortic arch replacement TAZ |
url |
https://www.frontiersin.org/articles/10.3389/fcvm.2020.587996/full |
work_keys_str_mv |
AT wenjianjiang tazisrelatedtopostoperativeinhospitalmortalityofacutetypeaaorticdissection AT wenjianjiang tazisrelatedtopostoperativeinhospitalmortalityofacutetypeaaorticdissection AT wenjianjiang tazisrelatedtopostoperativeinhospitalmortalityofacutetypeaaorticdissection AT yuanxue tazisrelatedtopostoperativeinhospitalmortalityofacutetypeaaorticdissection AT yuanxue tazisrelatedtopostoperativeinhospitalmortalityofacutetypeaaorticdissection AT yuanxue tazisrelatedtopostoperativeinhospitalmortalityofacutetypeaaorticdissection AT haibinli tazisrelatedtopostoperativeinhospitalmortalityofacutetypeaaorticdissection AT hongjiazhang tazisrelatedtopostoperativeinhospitalmortalityofacutetypeaaorticdissection AT hongjiazhang tazisrelatedtopostoperativeinhospitalmortalityofacutetypeaaorticdissection AT hongjiazhang tazisrelatedtopostoperativeinhospitalmortalityofacutetypeaaorticdissection AT yuanfeizhao tazisrelatedtopostoperativeinhospitalmortalityofacutetypeaaorticdissection |
_version_ |
1724532092578037760 |