Ex vivo expansion of CD3depleted cord blood-MNCs in the presence of bone marrow stromal cells; an appropriate strategy to provide functional NK cells applicable for cellular therapy

Ex vivo expansion of CD3depleted cord blood-MNCs in the presence of bone marrow stromal cells; an appropriate strategy to provide functional NK cells applicable for cellular therapy

Considering umbilical cord blood (UCB) as a rich source of hematopoietic stem cells, we introduced a cost-effective approach to expand CD3depleted UCB-MNCs into functional NK cells. CD3depleted UCB-MNCs were expanded in the presence or absence of a feeder [bone marrow stem cells (BMSCs) or osteoblas...

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Bibliographic Details
Main Authors: Ehteramolsadat Hosseini, Mehran Ghasemzadeh, Maedeh Kamalizad, Anthony P. Schwarer
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Stem Cell Research
Subjects:
BMSCs
CD3depleted mononuclear cells
Cytotoxicity
NK cell
Osteoblastic cells
Umbilical cord blood
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117300119

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