Differential Regulation of Type I and Type III Interferon Signaling
Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. There are three classes of IFNs: type I, type II and type III. While type II IFN is sp...
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doaj-6e32594dd91c46c4ba3a34f3ddcdc9bf2020-11-25T00:48:20ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-03-01206144510.3390/ijms20061445ijms20061445Differential Regulation of Type I and Type III Interferon SignalingMegan L. Stanifer0Kalliopi Pervolaraki1Steeve Boulant2Schaller Research Group at CellNetworks, Department of Infectious Diseases, Heidelberg University Hospital, 69120 Heidelberg, GermanySchaller Research Group at CellNetworks, Department of Infectious Diseases, Heidelberg University Hospital, 69120 Heidelberg, GermanySchaller Research Group at CellNetworks, Department of Infectious Diseases, Heidelberg University Hospital, 69120 Heidelberg, GermanyInterferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. There are three classes of IFNs: type I, type II and type III. While type II IFN is specific for immune cells, type I and III IFNs are expressed by both immune and tissue specific cells. Unlike type I IFNs, type III IFNs have a unique tropism where their signaling and functions are mostly restricted to epithelial cells. As such, this class of IFN has recently emerged as a key player in mucosal immunity. Since the discovery of type III IFNs, the last 15 years of research in the IFN field has focused on understanding whether the induction, the signaling and the function of these powerful cytokines are regulated differently compared to type I IFN-mediated immune response. This review will cover the current state of the knowledge of the similarities and differences in the signaling pathways emanating from type I and type III IFN stimulation.https://www.mdpi.com/1422-0067/20/6/1445Interferontype I IFNtype III IFNinterferon signalingJAK-STATsignal transduction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Megan L. Stanifer Kalliopi Pervolaraki Steeve Boulant |
spellingShingle |
Megan L. Stanifer Kalliopi Pervolaraki Steeve Boulant Differential Regulation of Type I and Type III Interferon Signaling International Journal of Molecular Sciences Interferon type I IFN type III IFN interferon signaling JAK-STAT signal transduction |
author_facet |
Megan L. Stanifer Kalliopi Pervolaraki Steeve Boulant |
author_sort |
Megan L. Stanifer |
title |
Differential Regulation of Type I and Type III Interferon Signaling |
title_short |
Differential Regulation of Type I and Type III Interferon Signaling |
title_full |
Differential Regulation of Type I and Type III Interferon Signaling |
title_fullStr |
Differential Regulation of Type I and Type III Interferon Signaling |
title_full_unstemmed |
Differential Regulation of Type I and Type III Interferon Signaling |
title_sort |
differential regulation of type i and type iii interferon signaling |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-03-01 |
description |
Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. There are three classes of IFNs: type I, type II and type III. While type II IFN is specific for immune cells, type I and III IFNs are expressed by both immune and tissue specific cells. Unlike type I IFNs, type III IFNs have a unique tropism where their signaling and functions are mostly restricted to epithelial cells. As such, this class of IFN has recently emerged as a key player in mucosal immunity. Since the discovery of type III IFNs, the last 15 years of research in the IFN field has focused on understanding whether the induction, the signaling and the function of these powerful cytokines are regulated differently compared to type I IFN-mediated immune response. This review will cover the current state of the knowledge of the similarities and differences in the signaling pathways emanating from type I and type III IFN stimulation. |
topic |
Interferon type I IFN type III IFN interferon signaling JAK-STAT signal transduction |
url |
https://www.mdpi.com/1422-0067/20/6/1445 |
work_keys_str_mv |
AT meganlstanifer differentialregulationoftypeiandtypeiiiinterferonsignaling AT kalliopipervolaraki differentialregulationoftypeiandtypeiiiinterferonsignaling AT steeveboulant differentialregulationoftypeiandtypeiiiinterferonsignaling |
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