Clonal architectures predict clinical outcome in clear cell renal cell carcinoma

Clonal architectures predict clinical outcome in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is a urogenital cancer with a well-defined genetic landscape. Here, the authors analyse the clonal architecture of ccRCC patients from three populations, and find prognostic subtypes linked to immune infiltrates and clonal architecture.

Bibliographic Details
Main Authors: Yi Huang, Jiayin Wang, Peilin Jia, Xiangchun Li, Guangsheng Pei, Changxi Wang, Xiaodong Fang, Zhongming Zhao, Zhiming Cai, Xin Yi, Song Wu, Baifeng Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09241-7
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spelling doaj-6e325ecbfb32442eb1a9e808c83d9a192021-05-11T12:11:31ZengNature Publishing GroupNature Communications2041-17232019-03-0110111010.1038/s41467-019-09241-7Clonal architectures predict clinical outcome in clear cell renal cell carcinomaYi Huang0Jiayin Wang1Peilin Jia2Xiangchun Li3Guangsheng Pei4Changxi Wang5Xiaodong Fang6Zhongming Zhao7Zhiming Cai8Xin Yi9Song Wu10Baifeng Zhang11Department of Computer Science and Technology, School of Electronic and Information Engineering, Xi’an Jiaotong UniversityDepartment of Computer Science and Technology, School of Electronic and Information Engineering, Xi’an Jiaotong UniversityCenter for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at HoustonDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and HospitalCenter for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at HoustonGeneplus-BeijingThe Second Affiliated Hospital of Guangzhou University of Chinese MedicineCenter for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at HoustonThe Third Affiliated Hospital of Shenzhen UniversityGeneplus-BeijingThe Third Affiliated Hospital of Shenzhen UniversityGeneplus-BeijingClear cell renal cell carcinoma (ccRCC) is a urogenital cancer with a well-defined genetic landscape. Here, the authors analyse the clonal architecture of ccRCC patients from three populations, and find prognostic subtypes linked to immune infiltrates and clonal architecture.https://doi.org/10.1038/s41467-019-09241-7
collection DOAJ
language English
format Article
sources DOAJ
author Yi Huang
Jiayin Wang
Peilin Jia
Xiangchun Li
Guangsheng Pei
Changxi Wang
Xiaodong Fang
Zhongming Zhao
Zhiming Cai
Xin Yi
Song Wu
Baifeng Zhang
spellingShingle Yi Huang
Jiayin Wang
Peilin Jia
Xiangchun Li
Guangsheng Pei
Changxi Wang
Xiaodong Fang
Zhongming Zhao
Zhiming Cai
Xin Yi
Song Wu
Baifeng Zhang
Clonal architectures predict clinical outcome in clear cell renal cell carcinoma
Nature Communications
author_facet Yi Huang
Jiayin Wang
Peilin Jia
Xiangchun Li
Guangsheng Pei
Changxi Wang
Xiaodong Fang
Zhongming Zhao
Zhiming Cai
Xin Yi
Song Wu
Baifeng Zhang
author_sort Yi Huang
title Clonal architectures predict clinical outcome in clear cell renal cell carcinoma
title_short Clonal architectures predict clinical outcome in clear cell renal cell carcinoma
title_full Clonal architectures predict clinical outcome in clear cell renal cell carcinoma
title_fullStr Clonal architectures predict clinical outcome in clear cell renal cell carcinoma
title_full_unstemmed Clonal architectures predict clinical outcome in clear cell renal cell carcinoma
title_sort clonal architectures predict clinical outcome in clear cell renal cell carcinoma
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-03-01
description Clear cell renal cell carcinoma (ccRCC) is a urogenital cancer with a well-defined genetic landscape. Here, the authors analyse the clonal architecture of ccRCC patients from three populations, and find prognostic subtypes linked to immune infiltrates and clonal architecture.
url https://doi.org/10.1038/s41467-019-09241-7
work_keys_str_mv AT yihuang clonalarchitecturespredictclinicaloutcomeinclearcellrenalcellcarcinoma
AT jiayinwang clonalarchitecturespredictclinicaloutcomeinclearcellrenalcellcarcinoma
AT peilinjia clonalarchitecturespredictclinicaloutcomeinclearcellrenalcellcarcinoma
AT xiangchunli clonalarchitecturespredictclinicaloutcomeinclearcellrenalcellcarcinoma
AT guangshengpei clonalarchitecturespredictclinicaloutcomeinclearcellrenalcellcarcinoma
AT changxiwang clonalarchitecturespredictclinicaloutcomeinclearcellrenalcellcarcinoma
AT xiaodongfang clonalarchitecturespredictclinicaloutcomeinclearcellrenalcellcarcinoma
AT zhongmingzhao clonalarchitecturespredictclinicaloutcomeinclearcellrenalcellcarcinoma
AT zhimingcai clonalarchitecturespredictclinicaloutcomeinclearcellrenalcellcarcinoma
AT xinyi clonalarchitecturespredictclinicaloutcomeinclearcellrenalcellcarcinoma
AT songwu clonalarchitecturespredictclinicaloutcomeinclearcellrenalcellcarcinoma
AT baifengzhang clonalarchitecturespredictclinicaloutcomeinclearcellrenalcellcarcinoma
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