RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer

RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer

Genetic polymorphisms in DNA repair genes may affect DNA repair efficiency and may contribute to the risk of developing cancer. The aim of our study was to investigate single nucleotide polymorphisms (SNPs) in RAD51 (rs2619679, rs2928140, and rs5030789) and XRCC3 (rs1799796) involved in DNA double-s...

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Main Authors: Maria Nowacka-Zawisza, Agata Raszkiewicz, Tomasz Kwasiborski, Ewa Forma, Magdalena Bryś, Waldemar Różański, Wanda M. Krajewska
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Oncology
Online Access:http://dx.doi.org/10.1155/2019/2976373
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spelling doaj-6e36b82d59254d8f9bd848e8bbcfe7ab2020-11-24T22:11:41ZengHindawi LimitedJournal of Oncology1687-84501687-84692019-01-01201910.1155/2019/29763732976373RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate CancerMaria Nowacka-Zawisza0Agata Raszkiewicz1Tomasz Kwasiborski2Ewa Forma3Magdalena Bryś4Waldemar Różański5Wanda M. Krajewska6Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, PolandDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, PolandDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, PolandDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, PolandDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, PolandDepartment of Urology 2, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Lodz, PolandDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, PolandGenetic polymorphisms in DNA repair genes may affect DNA repair efficiency and may contribute to the risk of developing cancer. The aim of our study was to investigate single nucleotide polymorphisms (SNPs) in RAD51 (rs2619679, rs2928140, and rs5030789) and XRCC3 (rs1799796) involved in DNA double-strand break repair and their relationship to prostate cancer. The study group included 99 men diagnosed with prostate cancer and 205 cancer-free controls. SNP genotyping was performed using the PCR-RFLP method. A significant association was detected between RAD51 rs5030789 polymorphism and XRCC3 rs1799796 polymorphism and an increased risk of prostate cancer. Our results indicate that RAD51 and XRCC3 polymorphism may contribute to prostate cancer.http://dx.doi.org/10.1155/2019/2976373
collection DOAJ
language English
format Article
sources DOAJ
author Maria Nowacka-Zawisza
Agata Raszkiewicz
Tomasz Kwasiborski
Ewa Forma
Magdalena Bryś
Waldemar Różański
Wanda M. Krajewska
spellingShingle Maria Nowacka-Zawisza
Agata Raszkiewicz
Tomasz Kwasiborski
Ewa Forma
Magdalena Bryś
Waldemar Różański
Wanda M. Krajewska
RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
Journal of Oncology
author_facet Maria Nowacka-Zawisza
Agata Raszkiewicz
Tomasz Kwasiborski
Ewa Forma
Magdalena Bryś
Waldemar Różański
Wanda M. Krajewska
author_sort Maria Nowacka-Zawisza
title RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
title_short RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
title_full RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
title_fullStr RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
title_full_unstemmed RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
title_sort rad51 and xrcc3 polymorphisms are associated with increased risk of prostate cancer
publisher Hindawi Limited
series Journal of Oncology
issn 1687-8450
1687-8469
publishDate 2019-01-01
description Genetic polymorphisms in DNA repair genes may affect DNA repair efficiency and may contribute to the risk of developing cancer. The aim of our study was to investigate single nucleotide polymorphisms (SNPs) in RAD51 (rs2619679, rs2928140, and rs5030789) and XRCC3 (rs1799796) involved in DNA double-strand break repair and their relationship to prostate cancer. The study group included 99 men diagnosed with prostate cancer and 205 cancer-free controls. SNP genotyping was performed using the PCR-RFLP method. A significant association was detected between RAD51 rs5030789 polymorphism and XRCC3 rs1799796 polymorphism and an increased risk of prostate cancer. Our results indicate that RAD51 and XRCC3 polymorphism may contribute to prostate cancer.
url http://dx.doi.org/10.1155/2019/2976373
work_keys_str_mv AT marianowackazawisza rad51andxrcc3polymorphismsareassociatedwithincreasedriskofprostatecancer
AT agataraszkiewicz rad51andxrcc3polymorphismsareassociatedwithincreasedriskofprostatecancer
AT tomaszkwasiborski rad51andxrcc3polymorphismsareassociatedwithincreasedriskofprostatecancer
AT ewaforma rad51andxrcc3polymorphismsareassociatedwithincreasedriskofprostatecancer
AT magdalenabrys rad51andxrcc3polymorphismsareassociatedwithincreasedriskofprostatecancer
AT waldemarrozanski rad51andxrcc3polymorphismsareassociatedwithincreasedriskofprostatecancer
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