Methylation Analysis of DNA Mismatch Repair Genes Using DNA Derived from the Peripheral Blood of Patients with Endometrial Cancer: Epimutation in Endometrial Carcinogenesis
Germline mutation of DNA mismatch repair (MMR) genes is a cause of Lynch syndrome. Methylation of MutL homolog 1 (MLH1) and MutS homolog 2 (MSH2) has been detected in peripheral blood cells of patients with colorectal cancer. This methylation is referred to as epimutation. Methylation of these genes...
Main Authors: | Takashi Takeda, Kouji Banno, Megumi Yanokura, Masataka Adachi, Moito Iijima, Haruko Kunitomi, Kanako Nakamura, Miho Iida, Yuya Nogami, Kiyoko Umene, Kenta Masuda, Yusuke Kobayashi, Wataru Yamagami, Akira Hirasawa, Eiichiro Tominaga, Nobuyuki Susumu, Daisuke Aoki |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2016-10-01
|
Series: | Genes |
Subjects: | |
Online Access: | http://www.mdpi.com/2073-4425/7/10/86 |
Similar Items
-
AlphaBeta: computational inference of epimutation rates and spectra from high-throughput DNA methylation data in plants
by: Yadollah Shahryary, et al.
Published: (2020-10-01) -
Epimutations, Inheritance and Causes of Aberrant DNA Methylation in Cancer
by: Mossman David, et al.
Published: (2006-05-01) -
Candidate Biomarkers for Genetic and Clinicopathological Diagnosis of Endometrial Cancer
by: Daisuke Aoki, et al.
Published: (2013-06-01) -
Epimutations are associated with CHROMOMETHYLASE 3-induced de novo DNA methylation
by: Jered M Wendte, et al.
Published: (2019-07-01) -
Epimutation of MMACHC compound to a genetic mutation in cblC cases
by: Xiaoman Zhang, et al.
Published: (2021-06-01)