Influence of Delivery Devices on Efficacy of Inhaled Fluticasone Propionate: A Comparative Study in Stable Asthma Patients
Background: Inhaled corticosteroids are the preferred treatment for long-term control of all grades of persistent asthma. These are administered by various delivery devices with very little information whether these devices can affect the efficacy of inhaled corticosteroids. Fluticasone propiona...
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doaj-6e4b5be8c9884b5c946450d873de10ff2020-11-25T03:18:59ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-09-01791908191210.7860/JCDR/2013/6705.3348Influence of Delivery Devices on Efficacy of Inhaled Fluticasone Propionate: A Comparative Study in Stable Asthma PatientsBhanu Prakash Kolasani0Venu Madhavi Lanke1Sudheer Diyya2Assistant Professor, Department of Pharmacology, Ragiv Gandhi Institute of Medical Sciences, Principal, RIMS, Kadapa, Andhra Pradesh, India.Assistant Professor, Department of Pharmacology, Ragiv Gandhi Institute of Medical Sciences, Putlampalli, Kadapa, Andhra Pradesh-516002, India.Assistant Professor, Department of Pulmonology, Ragiv Gandhi Institute of Medical Sciences, Putlampalli, Kadapa, Andhra Pradesh-516002, India.Background: Inhaled corticosteroids are the preferred treatment for long-term control of all grades of persistent asthma. These are administered by various delivery devices with very little information whether these devices can affect the efficacy of inhaled corticosteroids. Fluticasone propionate is a relatively new inhalational corticosteroid compared to older ones like beclomethasone and budesonide. Aims & Objective: To assess the relative efficacy of fluticasone propionate administered from different delivery devices to adult patients of chronic stable bronchial asthma as measured by pulmonary function test parameters. Material and Methods: This prospective study was undertaken to assess the relative efficacy of fluticasone propionate administered from different delivery devices to adult patients of chronic stable bronchial asthma as measured by pulmonary function test parameters. Fourty eight subjects were administered, fluticasone propionate (250 μg) by dry powder inhaler, metered dose inhaler, metered dose inhaler with spacer and fluticasone (1mg) via nebulizer consecutively each week for four weeks under direct supervision. Pulmonary function test was done before and one hour after administration of the drug on each visit. Results: After excluding nine patients who were lost to follow up, data was analysed for the remaining thirty nine patients and no significant difference in peak expiratory flow rate (p=0.77), forced expiratory volume in one second (p=0.95), forced vital capacity (p=0.24) and forced expiratory volume in one second and forced vital capacity ratio (p=0.22) was seen after giving fluticasone by different devices. Conclusion: Fluticasone propionate delivered by different devices like dry powder inhaler, metered dose inhaler, metered dose inhaler with spacer and nebulizer have similar effect on lung function in patients of chronic stable bronchial asthma and may be used interchangeably.https://jcdr.net/articles/PDF/3348/22-%206705_E(%20_%20)_PF1(%20_%20)_F(H)_PF1(P)_PF2(PP).pdfpeak expiratory flow rateforced vital capacitymetered dose inhalerfluticasone propionate |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bhanu Prakash Kolasani Venu Madhavi Lanke Sudheer Diyya |
spellingShingle |
Bhanu Prakash Kolasani Venu Madhavi Lanke Sudheer Diyya Influence of Delivery Devices on Efficacy of Inhaled Fluticasone Propionate: A Comparative Study in Stable Asthma Patients Journal of Clinical and Diagnostic Research peak expiratory flow rate forced vital capacity metered dose inhaler fluticasone propionate |
author_facet |
Bhanu Prakash Kolasani Venu Madhavi Lanke Sudheer Diyya |
author_sort |
Bhanu Prakash Kolasani |
title |
Influence of Delivery Devices on Efficacy of Inhaled Fluticasone Propionate: A Comparative Study in Stable Asthma Patients |
title_short |
Influence of Delivery Devices on Efficacy of Inhaled Fluticasone Propionate: A Comparative Study in Stable Asthma Patients |
title_full |
Influence of Delivery Devices on Efficacy of Inhaled Fluticasone Propionate: A Comparative Study in Stable Asthma Patients |
title_fullStr |
Influence of Delivery Devices on Efficacy of Inhaled Fluticasone Propionate: A Comparative Study in Stable Asthma Patients |
title_full_unstemmed |
Influence of Delivery Devices on Efficacy of Inhaled Fluticasone Propionate: A Comparative Study in Stable Asthma Patients |
title_sort |
influence of delivery devices on efficacy of inhaled fluticasone propionate: a comparative study in stable asthma patients |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2013-09-01 |
description |
Background: Inhaled corticosteroids are the preferred treatment
for long-term control of all grades of persistent asthma. These
are administered by various delivery devices with very little
information whether these devices can affect the efficacy of
inhaled corticosteroids. Fluticasone propionate is a relatively
new inhalational corticosteroid compared to older ones like
beclomethasone and budesonide.
Aims & Objective: To assess the relative efficacy of fluticasone
propionate administered from different delivery devices to adult
patients of chronic stable bronchial asthma as measured by
pulmonary function test parameters.
Material and Methods: This prospective study was undertaken
to assess the relative efficacy of fluticasone propionate
administered from different delivery devices to adult patients
of chronic stable bronchial asthma as measured by pulmonary
function test parameters. Fourty eight subjects were
administered, fluticasone propionate (250 μg) by dry powder
inhaler, metered dose inhaler, metered dose inhaler with spacer
and fluticasone (1mg) via nebulizer consecutively each week for
four weeks under direct supervision. Pulmonary function test
was done before and one hour after administration of the drug
on each visit.
Results: After excluding nine patients who were lost to follow
up, data was analysed for the remaining thirty nine patients and
no significant difference in peak expiratory flow rate (p=0.77),
forced expiratory volume in one second (p=0.95), forced vital
capacity (p=0.24) and forced expiratory volume in one second
and forced vital capacity ratio (p=0.22) was seen after giving
fluticasone by different devices.
Conclusion: Fluticasone propionate delivered by different
devices like dry powder inhaler, metered dose inhaler, metered
dose inhaler with spacer and nebulizer have similar effect on
lung function in patients of chronic stable bronchial asthma and
may be used interchangeably. |
topic |
peak expiratory flow rate forced vital capacity metered dose inhaler fluticasone propionate |
url |
https://jcdr.net/articles/PDF/3348/22-%206705_E(%20_%20)_PF1(%20_%20)_F(H)_PF1(P)_PF2(PP).pdf |
work_keys_str_mv |
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