Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants
‘Missing self’ is a mode of natural killer (NK) cell activation aimed to detect the lack of HLA-I molecules on infected or neoplastic cells. Here, the authors show that mismatch between donor HLA-I and cognate receptors on recipient NK cells mediates microvascular inflammation-associated graft rejec...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13113-5 |
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doaj-6e54e790902d416d9bb11f07312515cd2021-05-11T12:34:26ZengNature Publishing GroupNature Communications2041-17232019-11-0110111710.1038/s41467-019-13113-5Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplantsAlice Koenig0Chien-Chia Chen1Antoine Marçais2Thomas Barba3Virginie Mathias4Antoine Sicard5Maud Rabeyrin6Maud Racapé7Jean-Paul Duong-Van-Huyen8Patrick Bruneval9Alexandre Loupy10Sébastien Dussurgey11Stéphanie Ducreux12Vannary Meas-Yedid13Jean-Christophe Olivo-Marin14Héléna Paidassi15Romain Guillemain16Jean-Luc Taupin17Jasper Callemeyn18Emmanuel Morelon19Antonino Nicoletti20Béatrice Charreau21Valérie Dubois22Maarten Naesens23Thierry Walzer24Thierry Defrance25Olivier Thaunat26CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. LyonCIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. LyonCIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. LyonCIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. LyonCIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. LyonCIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. LyonHospices Civils de Lyon, Department of PathologyParis Translational Research Centre for Organ Transplantation, Paris Descartes UniversityParis Translational Research Centre for Organ Transplantation, Paris Descartes UniversityParis Translational Research Centre for Organ Transplantation, Paris Descartes UniversityParis Translational Research Centre for Organ Transplantation, Paris Descartes UniversitySFR Biosciences (UMS3444/CNRS, US8/Inserm, ENS de Lyon, UCBL)CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. LyonUnité d’Analyse d’Images Biologiques, Pasteur InstitutUnité d’Analyse d’Images Biologiques, Pasteur InstitutCIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. LyonAssistance Publique - Hôpitaux de Paris, Georges Pompidou Hospital, Cardiology and Heart Transplant DepartmentAssistance Publique - Hôpitaux de Paris, Immunology and HLA Laboratory, Saint-Louis HospitalDepartment of Microbiology and Immunology, KU Leuven, University of LeuvenCIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. LyonParis Diderot UniversityFrench National Institute of Health and Medical Research (Inserm) UMR1064CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. LyonDepartment of Microbiology and Immunology, KU Leuven, University of LeuvenCIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. LyonCIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. LyonCIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon‘Missing self’ is a mode of natural killer (NK) cell activation aimed to detect the lack of HLA-I molecules on infected or neoplastic cells. Here, the authors show that mismatch between donor HLA-I and cognate receptors on recipient NK cells mediates microvascular inflammation-associated graft rejection, a pathology that is preventable by mTOR inhibition.https://doi.org/10.1038/s41467-019-13113-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Alice Koenig Chien-Chia Chen Antoine Marçais Thomas Barba Virginie Mathias Antoine Sicard Maud Rabeyrin Maud Racapé Jean-Paul Duong-Van-Huyen Patrick Bruneval Alexandre Loupy Sébastien Dussurgey Stéphanie Ducreux Vannary Meas-Yedid Jean-Christophe Olivo-Marin Héléna Paidassi Romain Guillemain Jean-Luc Taupin Jasper Callemeyn Emmanuel Morelon Antonino Nicoletti Béatrice Charreau Valérie Dubois Maarten Naesens Thierry Walzer Thierry Defrance Olivier Thaunat |
| spellingShingle |
Alice Koenig Chien-Chia Chen Antoine Marçais Thomas Barba Virginie Mathias Antoine Sicard Maud Rabeyrin Maud Racapé Jean-Paul Duong-Van-Huyen Patrick Bruneval Alexandre Loupy Sébastien Dussurgey Stéphanie Ducreux Vannary Meas-Yedid Jean-Christophe Olivo-Marin Héléna Paidassi Romain Guillemain Jean-Luc Taupin Jasper Callemeyn Emmanuel Morelon Antonino Nicoletti Béatrice Charreau Valérie Dubois Maarten Naesens Thierry Walzer Thierry Defrance Olivier Thaunat Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants Nature Communications |
| author_facet |
Alice Koenig Chien-Chia Chen Antoine Marçais Thomas Barba Virginie Mathias Antoine Sicard Maud Rabeyrin Maud Racapé Jean-Paul Duong-Van-Huyen Patrick Bruneval Alexandre Loupy Sébastien Dussurgey Stéphanie Ducreux Vannary Meas-Yedid Jean-Christophe Olivo-Marin Héléna Paidassi Romain Guillemain Jean-Luc Taupin Jasper Callemeyn Emmanuel Morelon Antonino Nicoletti Béatrice Charreau Valérie Dubois Maarten Naesens Thierry Walzer Thierry Defrance Olivier Thaunat |
| author_sort |
Alice Koenig |
| title |
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants |
| title_short |
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants |
| title_full |
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants |
| title_fullStr |
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants |
| title_full_unstemmed |
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants |
| title_sort |
missing self triggers nk cell-mediated chronic vascular rejection of solid organ transplants |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-11-01 |
| description |
‘Missing self’ is a mode of natural killer (NK) cell activation aimed to detect the lack of HLA-I molecules on infected or neoplastic cells. Here, the authors show that mismatch between donor HLA-I and cognate receptors on recipient NK cells mediates microvascular inflammation-associated graft rejection, a pathology that is preventable by mTOR inhibition. |
| url |
https://doi.org/10.1038/s41467-019-13113-5 |
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