Benefits of caloric restriction in the myenteric neuronal plasticity in aging rats
Aging is a biologic process characterized by progressive damage of structures and functions of organic systems. In gastrointestinal tract, it can involve enteric nervous system, which plays an important role in digestion and absorption of nutrients, causing hastening of intestinal transit thus reduc...
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Academia Brasileira de Ciências
2014-09-01
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doaj-6e5938bebf8d473dbceab797c2b705ab2020-11-24T23:18:50ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902014-09-018631471148110.1590/0001-3765201420130052S0001-37652014000301471Benefits of caloric restriction in the myenteric neuronal plasticity in aging ratsJOICE N.B. PEREIRARENATA B. MARISANDRA R. STABILLEHAROLDO G. DE FARIATHAIS F.M. MOTAWALTER M. FERREIRAAging is a biologic process characterized by progressive damage of structures and functions of organic systems. In gastrointestinal tract, it can involve enteric nervous system, which plays an important role in digestion and absorption of nutrients, causing hastening of intestinal transit thus reducing its absorptive function. Caloric restriction has been used in several studies with the intention of delaying deleterious effects of aging. This study aimed to evaluate the effects of caloric restriction on myenteric neurons of ileum by aging in rats. 30 Wistar rats were grouped as follows: GI (animals aged 6 months fed with normal diet), GII (animals aged 18 months fed with normal diet) and GIII (animals aged 18 months subject to 31% of caloric restriction). The rats of the GI group were euthanized at 6 months of age and after experimental period of 12 months animals of the group GII and GIII were euthanized, the ileum of all groups were collected, measured and processed by NADPH-dp and Acetylcholinesterase. Quantitative analysis of neurons revealed that aging promotes the increasing of myenteric neurons NADPH-dp and reduces Acetylcholinesterase neuronal population. However, in the cellular profile area, were not observed significant differences between the groups. The caloric restriction has been efficient and can be used preventively because it minimizes quantitative changes associated with aging on ileum myenteric plexuses.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301471&lng=en&tlng=enenvelhecimentorestrição calóricaplexo mioentéricointestino delgado |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
JOICE N.B. PEREIRA RENATA B. MARI SANDRA R. STABILLE HAROLDO G. DE FARIA THAIS F.M. MOTA WALTER M. FERREIRA |
spellingShingle |
JOICE N.B. PEREIRA RENATA B. MARI SANDRA R. STABILLE HAROLDO G. DE FARIA THAIS F.M. MOTA WALTER M. FERREIRA Benefits of caloric restriction in the myenteric neuronal plasticity in aging rats Anais da Academia Brasileira de Ciências envelhecimento restrição calórica plexo mioentérico intestino delgado |
author_facet |
JOICE N.B. PEREIRA RENATA B. MARI SANDRA R. STABILLE HAROLDO G. DE FARIA THAIS F.M. MOTA WALTER M. FERREIRA |
author_sort |
JOICE N.B. PEREIRA |
title |
Benefits of caloric restriction in the myenteric neuronal plasticity in aging rats |
title_short |
Benefits of caloric restriction in the myenteric neuronal plasticity in aging rats |
title_full |
Benefits of caloric restriction in the myenteric neuronal plasticity in aging rats |
title_fullStr |
Benefits of caloric restriction in the myenteric neuronal plasticity in aging rats |
title_full_unstemmed |
Benefits of caloric restriction in the myenteric neuronal plasticity in aging rats |
title_sort |
benefits of caloric restriction in the myenteric neuronal plasticity in aging rats |
publisher |
Academia Brasileira de Ciências |
series |
Anais da Academia Brasileira de Ciências |
issn |
1678-2690 |
publishDate |
2014-09-01 |
description |
Aging is a biologic process characterized by progressive damage of structures and functions of organic systems. In gastrointestinal tract, it can involve enteric nervous system, which plays an important role in digestion and absorption of nutrients, causing hastening of intestinal transit thus reducing its absorptive function. Caloric restriction has been used in several studies with the intention of delaying deleterious effects of aging. This study aimed to evaluate the effects of caloric restriction on myenteric neurons of ileum by aging in rats. 30 Wistar rats were grouped as follows: GI (animals aged 6 months fed with normal diet), GII (animals aged 18 months fed with normal diet) and GIII (animals aged 18 months subject to 31% of caloric restriction). The rats of the GI group were euthanized at 6 months of age and after experimental period of 12 months animals of the group GII and GIII were euthanized, the ileum of all groups were collected, measured and processed by NADPH-dp and Acetylcholinesterase. Quantitative analysis of neurons revealed that aging promotes the increasing of myenteric neurons NADPH-dp and reduces Acetylcholinesterase neuronal population. However, in the cellular profile area, were not observed significant differences between the groups. The caloric restriction has been efficient and can be used preventively because it minimizes quantitative changes associated with aging on ileum myenteric plexuses. |
topic |
envelhecimento restrição calórica plexo mioentérico intestino delgado |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301471&lng=en&tlng=en |
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