PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome

PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome

Abstract Background Chronic diseases such as chagasic megaesophagus (secondary to Chagas’ disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are poorly understood. Objective We analyzed hotspot PIK3CA gene mutations...

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Bibliographic Details
Main Authors: Fernanda Franco Munari, Adriana Cruvinel-Carloni, Croider Franco Lacerda, Antônio Talvane Torres de Oliveira, Cristovam Scapulatempo-Neto, Sandra Regina Morini da Silva, Eduardo Crema, Sheila Jorge Adad, Maria Aparecida Marchesan Rodrigues, Maria Aparecida Coelho Arruda Henry, Denise Peixoto Guimarães, Adhemar Longatto-Filho, Rui Manuel Reis
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Infectious Agents and Cancer
Subjects:
Esophageal cancer
Trypanosoma cruzi
Achalasia
Esophageal squamous cell carcinoma
Chagasic megaesophagus
PIK3CA
Online Access:http://link.springer.com/article/10.1186/s13027-018-0216-3

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