Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut
Here, the authors tailor an acetylated galactoglucomannan (AcGGM) fibre from spruce wood to specifically enrich Roseburia and Faecalibacterium - beneficial species which have the enzymatic machinery to breakdown the fibre and generate butyrate. They subsequently perform a piglet feeding trial, metag...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19585-0 |
| id |
doaj-6e5fccddd70b4f2492963a10a80b13c2 |
|---|---|
| record_format |
Article |
| spelling |
doaj-6e5fccddd70b4f2492963a10a80b13c22021-05-11T09:07:35ZengNature Publishing GroupNature Communications2041-17232020-11-0111111510.1038/s41467-020-19585-0Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gutLeszek Michalak0John Christian Gaby1Leidy Lagos2Sabina Leanti La Rosa3Torgeir R. Hvidsten4Catherine Tétard-Jones5William G. T. Willats6Nicolas Terrapon7Vincent Lombard8Bernard Henrissat9Johannes Dröge10Magnus Øverlie Arntzen11Live Heldal Hagen12Margareth Øverland13Phillip B. Pope14Bjørge Westereng15Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life SciencesFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life SciencesFaculty of Biosciences, Norwegian University of Life SciencesFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life SciencesFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life SciencesSchool of Natural and Environmental Sciences, Newcastle UniversitySchool of Natural and Environmental Sciences, Newcastle UniversityCentre National de la Recherche Scientifique, Aix-Marseille UniversitéCentre National de la Recherche Scientifique, Aix-Marseille UniversitéCentre National de la Recherche Scientifique, Aix-Marseille UniversitéDepartment for Mathematical Sciences, Chalmers University of TechnologyFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life SciencesFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life SciencesFaculty of Biosciences, Norwegian University of Life SciencesFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life SciencesFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life SciencesHere, the authors tailor an acetylated galactoglucomannan (AcGGM) fibre from spruce wood to specifically enrich Roseburia and Faecalibacterium - beneficial species which have the enzymatic machinery to breakdown the fibre and generate butyrate. They subsequently perform a piglet feeding trial, metagenomics and metaproteomics, together showing that AcGGM-fed pigs exhibit not only increased Roseburia and Faecalibacterium populations with AcGGM-specific mannan-specific esterases, but also secondary metabolic pathways.https://doi.org/10.1038/s41467-020-19585-0 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Leszek Michalak John Christian Gaby Leidy Lagos Sabina Leanti La Rosa Torgeir R. Hvidsten Catherine Tétard-Jones William G. T. Willats Nicolas Terrapon Vincent Lombard Bernard Henrissat Johannes Dröge Magnus Øverlie Arntzen Live Heldal Hagen Margareth Øverland Phillip B. Pope Bjørge Westereng |
| spellingShingle |
Leszek Michalak John Christian Gaby Leidy Lagos Sabina Leanti La Rosa Torgeir R. Hvidsten Catherine Tétard-Jones William G. T. Willats Nicolas Terrapon Vincent Lombard Bernard Henrissat Johannes Dröge Magnus Øverlie Arntzen Live Heldal Hagen Margareth Øverland Phillip B. Pope Bjørge Westereng Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut Nature Communications |
| author_facet |
Leszek Michalak John Christian Gaby Leidy Lagos Sabina Leanti La Rosa Torgeir R. Hvidsten Catherine Tétard-Jones William G. T. Willats Nicolas Terrapon Vincent Lombard Bernard Henrissat Johannes Dröge Magnus Øverlie Arntzen Live Heldal Hagen Margareth Øverland Phillip B. Pope Bjørge Westereng |
| author_sort |
Leszek Michalak |
| title |
Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut |
| title_short |
Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut |
| title_full |
Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut |
| title_fullStr |
Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut |
| title_full_unstemmed |
Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut |
| title_sort |
microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-11-01 |
| description |
Here, the authors tailor an acetylated galactoglucomannan (AcGGM) fibre from spruce wood to specifically enrich Roseburia and Faecalibacterium - beneficial species which have the enzymatic machinery to breakdown the fibre and generate butyrate. They subsequently perform a piglet feeding trial, metagenomics and metaproteomics, together showing that AcGGM-fed pigs exhibit not only increased Roseburia and Faecalibacterium populations with AcGGM-specific mannan-specific esterases, but also secondary metabolic pathways. |
| url |
https://doi.org/10.1038/s41467-020-19585-0 |
| work_keys_str_mv |
AT leszekmichalak microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT johnchristiangaby microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT leidylagos microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT sabinaleantilarosa microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT torgeirrhvidsten microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT catherinetetardjones microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT williamgtwillats microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT nicolasterrapon microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT vincentlombard microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT bernardhenrissat microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT johannesdroge microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT magnusøverliearntzen microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT liveheldalhagen microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT margarethøverland microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT phillipbpope microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut AT bjørgewestereng microbiotadirectedfibreactivatesbothtargetedandsecondarymetabolicshiftsinthedistalgut |
| _version_ |
1721450212189274112 |