Diversity-oriented functionalization of 2-pyridones and uracils

Diversity-oriented functionalization of 2-pyridones and uracils

Diversity-oriented synthesis of 2-pyridone and uracil derivatives is in urgent need in medicinal chemistry as they are useful pharmacophores. Here the authors show that palladium/norbornene cooperative catalysis enabled dual-functionalization of iodinated 2- pyridones and uracils.

Bibliographic Details
Main Authors: Yong Shang, Chenggui Wu, Qianwen Gao, Chang Liu, Lisha Li, Xinping Zhang, Hong-Gang Cheng, Shanshan Liu, Qianghui Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23058-3
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spelling doaj-6e648b9aff0148d28469f0aab4b175e12021-05-23T11:13:33ZengNature Publishing GroupNature Communications2041-17232021-05-0112111110.1038/s41467-021-23058-3Diversity-oriented functionalization of 2-pyridones and uracilsYong Shang0Chenggui Wu1Qianwen Gao2Chang Liu3Lisha Li4Xinping Zhang5Hong-Gang Cheng6Shanshan Liu7Qianghui Zhou8Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), College of Chemistry and Molecular Sciences, and The Institute for Advanced StudiesSauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), College of Chemistry and Molecular Sciences, and The Institute for Advanced StudiesSauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), College of Chemistry and Molecular Sciences, and The Institute for Advanced StudiesSauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), College of Chemistry and Molecular Sciences, and The Institute for Advanced StudiesSauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), College of Chemistry and Molecular Sciences, and The Institute for Advanced StudiesSauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), College of Chemistry and Molecular Sciences, and The Institute for Advanced StudiesSauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), College of Chemistry and Molecular Sciences, and The Institute for Advanced StudiesSauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), College of Chemistry and Molecular Sciences, and The Institute for Advanced StudiesSauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), College of Chemistry and Molecular Sciences, and The Institute for Advanced StudiesDiversity-oriented synthesis of 2-pyridone and uracil derivatives is in urgent need in medicinal chemistry as they are useful pharmacophores. Here the authors show that palladium/norbornene cooperative catalysis enabled dual-functionalization of iodinated 2- pyridones and uracils.https://doi.org/10.1038/s41467-021-23058-3
collection DOAJ
language English
format Article
sources DOAJ
author Yong Shang
Chenggui Wu
Qianwen Gao
Chang Liu
Lisha Li
Xinping Zhang
Hong-Gang Cheng
Shanshan Liu
Qianghui Zhou
spellingShingle Yong Shang
Chenggui Wu
Qianwen Gao
Chang Liu
Lisha Li
Xinping Zhang
Hong-Gang Cheng
Shanshan Liu
Qianghui Zhou
Diversity-oriented functionalization of 2-pyridones and uracils
Nature Communications
author_facet Yong Shang
Chenggui Wu
Qianwen Gao
Chang Liu
Lisha Li
Xinping Zhang
Hong-Gang Cheng
Shanshan Liu
Qianghui Zhou
author_sort Yong Shang
title Diversity-oriented functionalization of 2-pyridones and uracils
title_short Diversity-oriented functionalization of 2-pyridones and uracils
title_full Diversity-oriented functionalization of 2-pyridones and uracils
title_fullStr Diversity-oriented functionalization of 2-pyridones and uracils
title_full_unstemmed Diversity-oriented functionalization of 2-pyridones and uracils
title_sort diversity-oriented functionalization of 2-pyridones and uracils
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description Diversity-oriented synthesis of 2-pyridone and uracil derivatives is in urgent need in medicinal chemistry as they are useful pharmacophores. Here the authors show that palladium/norbornene cooperative catalysis enabled dual-functionalization of iodinated 2- pyridones and uracils.
url https://doi.org/10.1038/s41467-021-23058-3
work_keys_str_mv AT yongshang diversityorientedfunctionalizationof2pyridonesanduracils
AT chengguiwu diversityorientedfunctionalizationof2pyridonesanduracils
AT qianwengao diversityorientedfunctionalizationof2pyridonesanduracils
AT changliu diversityorientedfunctionalizationof2pyridonesanduracils
AT lishali diversityorientedfunctionalizationof2pyridonesanduracils
AT xinpingzhang diversityorientedfunctionalizationof2pyridonesanduracils
AT honggangcheng diversityorientedfunctionalizationof2pyridonesanduracils
AT shanshanliu diversityorientedfunctionalizationof2pyridonesanduracils
AT qianghuizhou diversityorientedfunctionalizationof2pyridonesanduracils
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