Discovery of myricetin as an inhibitor against Streptococcus mutans and an anti-adhesion approach to biofilm formation

Discovery of myricetin as an inhibitor against Streptococcus mutans and an anti-adhesion approach to biofilm formation

Streptococcus mutans (S. mutans) are cariogenic microorganisms. Sortase A (SrtA) is a transpeptidase that attaches Pac to the cell surface. The biofilm formation of S. mutans is promoted by SrtA regulated Pac. Myricetin (Myr) has a variety of pharmacological properties, including inhibiting SrtA act...

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Bibliographic Details
Main Authors: Ping Hu, Bibo Lv, Kongxi Yang, Zimin Lu, Jingzhi Ma
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:International Journal of Medical Microbiology
Subjects:
Streptococcus mutans
Sortase A
Myricetin
Inhibitors
Molecular dynamics
Biofilm
Online Access:http://www.sciencedirect.com/science/article/pii/S1438422121000412

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