Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort Study
Objective: As a recently defined disease entity, vestibular migraine (VM) is a variant of migraine with broad spectrum of manifestations. We evaluated a prospective cohort of patients with VM in two centers to assess severity of VM attacks and investigate its contributing factors in patients with VM...
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doaj-6e6c6b241832440dbe0878f5ecc1d12a2020-12-16T04:58:19ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-12-011110.3389/fneur.2020.595328595328Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort StudyWei Liu0Wei Liu1Hongli Dong2Le Yang3Hongru Zhao4Wanli Dong5Yi Yang6Departments of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaDepartment of Neurology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaSchool of Public Health, Fujian Medical University, Fuzhou, ChinaDepartments of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartments of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartments of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaObjective: As a recently defined disease entity, vestibular migraine (VM) is a variant of migraine with broad spectrum of manifestations. We evaluated a prospective cohort of patients with VM in two centers to assess severity of VM attacks and investigate its contributing factors in patients with VM.Methods: Adult participants with the diagnosis of VM or probable VM were enrolled according to the 2012 International Headache Society-Bárány Society Criteria. Every outpatient was followed up for 6 months to record the occurrence of VM attacks. Clinical data such as age, sex, number of VM attacks, severity on the visual analog scale, and lipid intake were collected and analyzed. Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, Horne and Ostberg Morningness-Eveningness Questionnaires, and Pittsburgh Sleep Quality Index were also administered to find contributing factors.Results: During a 6-month clinical follow-up, 313 VM attack were reported. According to the Visual Analog Scale, the patients were divided into two groups. Then univariate and multivariable analyses were conducted. Among the risk factors, duration of illness (adjusted OR, 1.041; 95% CI, 1.010–1.073; P = 0.009), time of onset: 00:00:00–12:00:00 (adjusted OR, 3.961; 95% CI, 1.966–7.979; P < 0.001) and PSQI scores (adjusted OR, 1.086; 95% CI, 1.002–1.178; P = 0.046) were significantly associated with the severity of VM attack assessed by VAS.Conclusion: The data suggest that patients tended to experienced more severe VM attacks in early hours of a day, especially for those sufferers with longer duration of illness or poor sleep quality. Targeted management of such factors is required to reduce the severity of attacks.https://www.frontiersin.org/articles/10.3389/fneur.2020.595328/fullvestibular migraineseverityclinical presentationcontributing factorscircadian variations |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei Liu Wei Liu Hongli Dong Le Yang Hongru Zhao Wanli Dong Yi Yang |
spellingShingle |
Wei Liu Wei Liu Hongli Dong Le Yang Hongru Zhao Wanli Dong Yi Yang Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort Study Frontiers in Neurology vestibular migraine severity clinical presentation contributing factors circadian variations |
author_facet |
Wei Liu Wei Liu Hongli Dong Le Yang Hongru Zhao Wanli Dong Yi Yang |
author_sort |
Wei Liu |
title |
Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort Study |
title_short |
Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort Study |
title_full |
Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort Study |
title_fullStr |
Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort Study |
title_full_unstemmed |
Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort Study |
title_sort |
severity and its contributing factors in patients with vestibular migraine: a cohort study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2020-12-01 |
description |
Objective: As a recently defined disease entity, vestibular migraine (VM) is a variant of migraine with broad spectrum of manifestations. We evaluated a prospective cohort of patients with VM in two centers to assess severity of VM attacks and investigate its contributing factors in patients with VM.Methods: Adult participants with the diagnosis of VM or probable VM were enrolled according to the 2012 International Headache Society-Bárány Society Criteria. Every outpatient was followed up for 6 months to record the occurrence of VM attacks. Clinical data such as age, sex, number of VM attacks, severity on the visual analog scale, and lipid intake were collected and analyzed. Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, Horne and Ostberg Morningness-Eveningness Questionnaires, and Pittsburgh Sleep Quality Index were also administered to find contributing factors.Results: During a 6-month clinical follow-up, 313 VM attack were reported. According to the Visual Analog Scale, the patients were divided into two groups. Then univariate and multivariable analyses were conducted. Among the risk factors, duration of illness (adjusted OR, 1.041; 95% CI, 1.010–1.073; P = 0.009), time of onset: 00:00:00–12:00:00 (adjusted OR, 3.961; 95% CI, 1.966–7.979; P < 0.001) and PSQI scores (adjusted OR, 1.086; 95% CI, 1.002–1.178; P = 0.046) were significantly associated with the severity of VM attack assessed by VAS.Conclusion: The data suggest that patients tended to experienced more severe VM attacks in early hours of a day, especially for those sufferers with longer duration of illness or poor sleep quality. Targeted management of such factors is required to reduce the severity of attacks. |
topic |
vestibular migraine severity clinical presentation contributing factors circadian variations |
url |
https://www.frontiersin.org/articles/10.3389/fneur.2020.595328/full |
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