Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis
Background/Aim. Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. However, data is limited to a few ethnicities and no similar study has been performed in middle eastern populations. We investigated this association in Saudi psoriasis patients. Methods. Saudi subj...
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Series: | Disease Markers |
Online Access: | http://dx.doi.org/10.1155/2014/239645 |
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doaj-6e9231dd2b4848bdbe06026e46c7470f2020-11-24T20:42:24ZengHindawi LimitedDisease Markers0278-02401875-86302014-01-01201410.1155/2014/239645239645Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with PsoriasisFahad Al Harthi0Ghaleb Bin Huraib1Abdulrahman Zouman2Misbahul Arfin3Mohammad Tariq4Abdulrahaman Al-Asmari5Department of Dermatology, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi ArabiaDepartment of Dermatology, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi ArabiaDepartment of Dermatology, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi ArabiaResearch Center, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi ArabiaResearch Center, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi ArabiaResearch Center, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi ArabiaBackground/Aim. Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. However, data is limited to a few ethnicities and no similar study has been performed in middle eastern populations. We investigated this association in Saudi psoriasis patients. Methods. Saudi subjects (294) were genotyped for APOE gene using APOE StripAssay kit. Results. The frequencies of alleles ε2, ε4, and genotypes ε3/ε4 and ε3/ε2 were significantly higher in psoriasis patients compared with those in controls. The frequency of ε3 allele and ε3/ε3 genotype was significantly lower in patients. Other genotypes, ε2/ε4, ε2/ε2, and ε4/ε4, were absent in both groups. The serum cholesterol, triglycerides, and LDL levels were significantly higher in psoriasis patients contrary to HDL level. Patients with APOE ε4 had significantly higher levels of total cholesterol and LDL cholesterol, whereas those with the ε2 had higher HDL cholesterol, and triglycerides. Conclusion. APOE alleles ε2, ε4, and genotypes ε2/ε3 and ε4/ε3 are associated with psoriasis and can be a risk factor while allele ε3 and genotype ε3/ε3 may be protective for psoriasis in Saudis. Results of lipid profile support that psoriasis is one of the independent risk factors for hyperlipidemia and emphasize the need of screening cardiovascular diseases in psoriatic patients.http://dx.doi.org/10.1155/2014/239645 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fahad Al Harthi Ghaleb Bin Huraib Abdulrahman Zouman Misbahul Arfin Mohammad Tariq Abdulrahaman Al-Asmari |
spellingShingle |
Fahad Al Harthi Ghaleb Bin Huraib Abdulrahman Zouman Misbahul Arfin Mohammad Tariq Abdulrahaman Al-Asmari Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis Disease Markers |
author_facet |
Fahad Al Harthi Ghaleb Bin Huraib Abdulrahman Zouman Misbahul Arfin Mohammad Tariq Abdulrahaman Al-Asmari |
author_sort |
Fahad Al Harthi |
title |
Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis |
title_short |
Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis |
title_full |
Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis |
title_fullStr |
Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis |
title_full_unstemmed |
Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis |
title_sort |
apolipoprotein e gene polymorphism and serum lipid profile in saudi patients with psoriasis |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2014-01-01 |
description |
Background/Aim. Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. However, data is limited to a few ethnicities and no similar study has been performed in middle eastern populations. We investigated this association in Saudi psoriasis patients. Methods. Saudi subjects (294) were genotyped for APOE gene using APOE StripAssay kit. Results. The frequencies of alleles ε2, ε4, and genotypes ε3/ε4 and ε3/ε2 were significantly higher in psoriasis patients compared with those in controls. The frequency of ε3 allele and ε3/ε3 genotype was significantly lower in patients. Other genotypes, ε2/ε4, ε2/ε2, and ε4/ε4, were absent in both groups. The serum cholesterol, triglycerides, and LDL levels were significantly higher in psoriasis patients contrary to HDL level. Patients with APOE ε4 had significantly higher levels of total cholesterol and LDL cholesterol, whereas those with the ε2 had higher HDL cholesterol, and triglycerides. Conclusion. APOE alleles ε2, ε4, and genotypes ε2/ε3 and ε4/ε3 are associated with psoriasis and can be a risk factor while allele ε3 and genotype ε3/ε3 may be protective for psoriasis in Saudis. Results of lipid profile support that psoriasis is one of the independent risk factors for hyperlipidemia and emphasize the need of screening cardiovascular diseases in psoriatic patients. |
url |
http://dx.doi.org/10.1155/2014/239645 |
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