Comparative Evaluation of Efficacy, Safety and Haemostatic Parameters of Enoxaparin and Fondaparinux in Unstable Coronary Artery Disease
Aim: To compare the safety and efficacy of Enoxaparin (EX) and Fondaparinux (FD) in patients with Unstable Coronary Artery Disease (UCAD). Materials and Methods: A prospective, open label, randomized comparative study was designed to study the comparative efficacy and safety of EX and FD in UCA...
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doaj-6e929126ad074af4a09c4b17e06cf7bb2020-11-25T03:35:14ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-01-0181313410.7860/JCDR/2014/6359.3908Comparative Evaluation of Efficacy, Safety and Haemostatic Parameters of Enoxaparin and Fondaparinux in Unstable Coronary Artery DiseaseSanjay Shah0Vijay Khajuria1Vishal R. Tandon2Zahid H.Gillani3Mohan Lal4Senior Demonstrator, Department of Pharmacology, Government Medical College, Jammu and Kashmir, India.Associate Professor, Department of Pharmacology, Government Medical College, Jammu and Kashmir, India.Assistant Professor, Department of Pharmacology, Government Medical College, Jammu and Kashmir, India.Professor and Head, Department of Pharmacology, Government Medical College, Jammu and Kashmir, India.Ex-Professor & Head, Department of Cardiology, Government Medical College, Jammu and Kashmir, India.Aim: To compare the safety and efficacy of Enoxaparin (EX) and Fondaparinux (FD) in patients with Unstable Coronary Artery Disease (UCAD). Materials and Methods: A prospective, open label, randomized comparative study was designed to study the comparative efficacy and safety of EX and FD in UCAD patients. Recovery, recurrence, major and minor bleeding and biochemical investigations were evaluated and compared among two arms. Results: The baseline demographic characteristics were similar in both groups, with mean age of 56.05 and 56.05 years in EX and FD group respectively. Recovery was equal in two arms. Recurrent MI or angina was seen numerically more in EX group, but it did not statistically vary from that in the FD group. Incidence of haemorrhage was similar in both groups at 9 days, but at 30 days, EX showed a higher incidence (p<0.05). Deaths were prevented in both the treatment arms. Bleeding parameters such as BT, CT and platelet count were not altered in both groups. Conclusion: FD appeared to be better than EX in efficacy, as was indicated by a numerically more decrease in recurrence of angina or MI. FD regimen group also had better safety profile, as there was no incidence of haemorrhage at 30 days Therefore, we conclude that FD is an attractive option than EX in UCAD patients.https://jcdr.net/articles/PDF/3908/10-6359_E(C)_F(T)_PF1(MH)_PFA(H)_PFA(Ak)_PF2(RKH).pdfanticoagulantslow molecular weight heparinenoxaparinfondaparinux |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sanjay Shah Vijay Khajuria Vishal R. Tandon Zahid H.Gillani Mohan Lal |
spellingShingle |
Sanjay Shah Vijay Khajuria Vishal R. Tandon Zahid H.Gillani Mohan Lal Comparative Evaluation of Efficacy, Safety and Haemostatic Parameters of Enoxaparin and Fondaparinux in Unstable Coronary Artery Disease Journal of Clinical and Diagnostic Research anticoagulants low molecular weight heparin enoxaparin fondaparinux |
author_facet |
Sanjay Shah Vijay Khajuria Vishal R. Tandon Zahid H.Gillani Mohan Lal |
author_sort |
Sanjay Shah |
title |
Comparative Evaluation of Efficacy, Safety and Haemostatic Parameters of Enoxaparin and Fondaparinux in Unstable Coronary Artery Disease |
title_short |
Comparative Evaluation of Efficacy, Safety and Haemostatic Parameters of Enoxaparin and Fondaparinux in Unstable Coronary Artery Disease |
title_full |
Comparative Evaluation of Efficacy, Safety and Haemostatic Parameters of Enoxaparin and Fondaparinux in Unstable Coronary Artery Disease |
title_fullStr |
Comparative Evaluation of Efficacy, Safety and Haemostatic Parameters of Enoxaparin and Fondaparinux in Unstable Coronary Artery Disease |
title_full_unstemmed |
Comparative Evaluation of Efficacy, Safety and Haemostatic Parameters of Enoxaparin and Fondaparinux in Unstable Coronary Artery Disease |
title_sort |
comparative evaluation of efficacy, safety and haemostatic parameters of enoxaparin and fondaparinux in unstable coronary artery disease |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2014-01-01 |
description |
Aim: To compare the safety and efficacy of Enoxaparin (EX) and
Fondaparinux (FD) in patients with Unstable Coronary Artery
Disease (UCAD).
Materials and Methods: A prospective, open label, randomized
comparative study was designed to study the comparative efficacy
and safety of EX and FD in UCAD patients. Recovery, recurrence,
major and minor bleeding and biochemical investigations were
evaluated and compared among two arms.
Results: The baseline demographic characteristics were similar
in both groups, with mean age of 56.05 and 56.05 years in EX
and FD group respectively. Recovery was equal in two arms.
Recurrent MI or angina was seen numerically more in EX group,
but it did not statistically vary from that in the FD group. Incidence
of haemorrhage was similar in both groups at 9 days, but at
30 days, EX showed a higher incidence (p<0.05). Deaths were
prevented in both the treatment arms. Bleeding parameters such
as BT, CT and platelet count were not altered in both groups.
Conclusion: FD appeared to be better than EX in efficacy, as
was indicated by a numerically more decrease in recurrence of
angina or MI. FD regimen group also had better safety profile, as
there was no incidence of haemorrhage at 30 days Therefore,
we conclude that FD is an attractive option than EX in UCAD
patients. |
topic |
anticoagulants low molecular weight heparin enoxaparin fondaparinux |
url |
https://jcdr.net/articles/PDF/3908/10-6359_E(C)_F(T)_PF1(MH)_PFA(H)_PFA(Ak)_PF2(RKH).pdf |
work_keys_str_mv |
AT sanjayshah comparativeevaluationofefficacysafetyandhaemostaticparametersofenoxaparinandfondaparinuxinunstablecoronaryarterydisease AT vijaykhajuria comparativeevaluationofefficacysafetyandhaemostaticparametersofenoxaparinandfondaparinuxinunstablecoronaryarterydisease AT vishalrtandon comparativeevaluationofefficacysafetyandhaemostaticparametersofenoxaparinandfondaparinuxinunstablecoronaryarterydisease AT zahidhgillani comparativeevaluationofefficacysafetyandhaemostaticparametersofenoxaparinandfondaparinuxinunstablecoronaryarterydisease AT mohanlal comparativeevaluationofefficacysafetyandhaemostaticparametersofenoxaparinandfondaparinuxinunstablecoronaryarterydisease |
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