Development and characterization of pullulan-polymethacrylate free films as potential material for enteric drug release
ABSTRACT Free films of pullulan-polymethacrylate associations were produced by casting process to develop a novel target-specific material. For characterization, tests of water vapor permeability, swelling index, infrared absorption spectroscopy, thermogravimetric analysis, scanning electron microsc...
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Universidade de São Paulo
2017-07-01
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doaj-6e96739ead2e4f2783dba83b31de9f6c2020-11-25T01:44:54ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902017-07-0153310.1590/s2175-97902017000300002S1984-82502017000300601Development and characterization of pullulan-polymethacrylate free films as potential material for enteric drug releaseIsabela Angeli de LimaSuelen Plaza PominOsvaldo Albuquerque CavalcantiABSTRACT Free films of pullulan-polymethacrylate associations were produced by casting process to develop a novel target-specific material. For characterization, tests of water vapor permeability, swelling index, infrared absorption spectroscopy, thermogravimetric analysis, scanning electron microscopy and mechanical analysis were performed. The polysaccharide concentration directly influenced vapor permeability and swelling, increasing the values of the latter up to five times when added in a proportion of 20% (per weight). The individual properties of each polymer were maintained, and chemical interactions were not detected. The films were found to be thermally stable and they had unaltered mechanical properties with the addition of the polysaccharide. The microscopic analysis revealed rugosity that was proportional to pullulan and disorganization of the polymer network at pH 6.8. These results suggest that this novel material has potential for enteric drug release because of synergism between pH and enzyme dependence.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300601&lng=en&tlng=enFilmsPolymeric materialModified release/enteric release/oral delivery/controlled releaseGlucansEudragitPhysicochemical characterization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isabela Angeli de Lima Suelen Plaza Pomin Osvaldo Albuquerque Cavalcanti |
spellingShingle |
Isabela Angeli de Lima Suelen Plaza Pomin Osvaldo Albuquerque Cavalcanti Development and characterization of pullulan-polymethacrylate free films as potential material for enteric drug release Brazilian Journal of Pharmaceutical Sciences Films Polymeric material Modified release/enteric release/oral delivery/controlled release Glucans Eudragit Physicochemical characterization |
author_facet |
Isabela Angeli de Lima Suelen Plaza Pomin Osvaldo Albuquerque Cavalcanti |
author_sort |
Isabela Angeli de Lima |
title |
Development and characterization of pullulan-polymethacrylate free films as potential material for enteric drug release |
title_short |
Development and characterization of pullulan-polymethacrylate free films as potential material for enteric drug release |
title_full |
Development and characterization of pullulan-polymethacrylate free films as potential material for enteric drug release |
title_fullStr |
Development and characterization of pullulan-polymethacrylate free films as potential material for enteric drug release |
title_full_unstemmed |
Development and characterization of pullulan-polymethacrylate free films as potential material for enteric drug release |
title_sort |
development and characterization of pullulan-polymethacrylate free films as potential material for enteric drug release |
publisher |
Universidade de São Paulo |
series |
Brazilian Journal of Pharmaceutical Sciences |
issn |
2175-9790 |
publishDate |
2017-07-01 |
description |
ABSTRACT Free films of pullulan-polymethacrylate associations were produced by casting process to develop a novel target-specific material. For characterization, tests of water vapor permeability, swelling index, infrared absorption spectroscopy, thermogravimetric analysis, scanning electron microscopy and mechanical analysis were performed. The polysaccharide concentration directly influenced vapor permeability and swelling, increasing the values of the latter up to five times when added in a proportion of 20% (per weight). The individual properties of each polymer were maintained, and chemical interactions were not detected. The films were found to be thermally stable and they had unaltered mechanical properties with the addition of the polysaccharide. The microscopic analysis revealed rugosity that was proportional to pullulan and disorganization of the polymer network at pH 6.8. These results suggest that this novel material has potential for enteric drug release because of synergism between pH and enzyme dependence. |
topic |
Films Polymeric material Modified release/enteric release/oral delivery/controlled release Glucans Eudragit Physicochemical characterization |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300601&lng=en&tlng=en |
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