Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives
Gliomas have poor prognosis no matter the treatment applied, remaining an unmet clinical need. As background for a substantial change in this situation, this review will focus on the following points: (i) the steady progress in establishing the role of molecular chaperones in carcinogenesis; (ii) th...
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2018-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/9/2626 |
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doaj-6e9812b77a6249a5837d80de7e078d752020-11-24T22:04:17ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-09-01199262610.3390/ijms19092626ijms19092626Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics PerspectivesCeleste Caruso Bavisotto0Francesca Graziano1Francesca Rappa2Antonella Marino Gammazza3Mariantonia Logozzi4Stefano Fais5Rosario Maugeri6Fabio Bucchieri7Everly Conway de Macario8Alberto J. L. Macario9Francesco Cappello10Domenico G. Iacopino11Claudia Campanella12Department of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Neurosurgery, University of Palermo, 90127 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyDepartment of Oncology and Molecular Medicine, National Institute of Health, Viale Regina Elena 299, 00161 Rome, ItalyDepartment of Oncology and Molecular Medicine, National Institute of Health, Viale Regina Elena 299, 00161 Rome, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Neurosurgery, University of Palermo, 90127 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyDepartment of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore-Institute of Marine and Environmental Technology (IMET), Baltimore, MD 21202, USAEuro-Mediterranean Institute of Science and Technology (IEMEST), 90136 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Neurosurgery, University of Palermo, 90127 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyGliomas have poor prognosis no matter the treatment applied, remaining an unmet clinical need. As background for a substantial change in this situation, this review will focus on the following points: (i) the steady progress in establishing the role of molecular chaperones in carcinogenesis; (ii) the recent advances in the knowledge of miRNAs in regulating gene expression, including genes involved in carcinogenesis and genes encoding chaperones; and (iii) the findings about exosomes and their cargo released by tumor cells. We would like to trigger a discussion about the involvement of exosomal chaperones and miRNAs in gliomagenesis. Chaperones may be either targets for therapy, due to their tumor-promoting activity, or therapeutic agents, due to their antitumor growth activity. Thus, chaperones may well represent a Janus-faced approach against tumors. This review focuses on extracellular chaperones as part of exosomes’ cargo, because of their potential as a new tool for the diagnosis and management of gliomas. Moreover, since exosomes transport chaperones and miRNAs (the latter possibly related to chaperone gene expression in the recipient cell), and probably deliver their cargo in the recipient cells, a new area of investigation is now open, which is bound to generate significant advances in the understanding and treatment of gliomas.http://www.mdpi.com/1422-0067/19/9/2626gliomasmolecular chaperonesHsps (Heat shock proteins)Hsp60miRNAexosomesextracellular vesiclestheranostic tools |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Celeste Caruso Bavisotto Francesca Graziano Francesca Rappa Antonella Marino Gammazza Mariantonia Logozzi Stefano Fais Rosario Maugeri Fabio Bucchieri Everly Conway de Macario Alberto J. L. Macario Francesco Cappello Domenico G. Iacopino Claudia Campanella |
| spellingShingle |
Celeste Caruso Bavisotto Francesca Graziano Francesca Rappa Antonella Marino Gammazza Mariantonia Logozzi Stefano Fais Rosario Maugeri Fabio Bucchieri Everly Conway de Macario Alberto J. L. Macario Francesco Cappello Domenico G. Iacopino Claudia Campanella Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives International Journal of Molecular Sciences gliomas molecular chaperones Hsps (Heat shock proteins) Hsp60 miRNA exosomes extracellular vesicles theranostic tools |
| author_facet |
Celeste Caruso Bavisotto Francesca Graziano Francesca Rappa Antonella Marino Gammazza Mariantonia Logozzi Stefano Fais Rosario Maugeri Fabio Bucchieri Everly Conway de Macario Alberto J. L. Macario Francesco Cappello Domenico G. Iacopino Claudia Campanella |
| author_sort |
Celeste Caruso Bavisotto |
| title |
Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives |
| title_short |
Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives |
| title_full |
Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives |
| title_fullStr |
Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives |
| title_full_unstemmed |
Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives |
| title_sort |
exosomal chaperones and mirnas in gliomagenesis: state-of-art and theranostics perspectives |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1422-0067 |
| publishDate |
2018-09-01 |
| description |
Gliomas have poor prognosis no matter the treatment applied, remaining an unmet clinical need. As background for a substantial change in this situation, this review will focus on the following points: (i) the steady progress in establishing the role of molecular chaperones in carcinogenesis; (ii) the recent advances in the knowledge of miRNAs in regulating gene expression, including genes involved in carcinogenesis and genes encoding chaperones; and (iii) the findings about exosomes and their cargo released by tumor cells. We would like to trigger a discussion about the involvement of exosomal chaperones and miRNAs in gliomagenesis. Chaperones may be either targets for therapy, due to their tumor-promoting activity, or therapeutic agents, due to their antitumor growth activity. Thus, chaperones may well represent a Janus-faced approach against tumors. This review focuses on extracellular chaperones as part of exosomes’ cargo, because of their potential as a new tool for the diagnosis and management of gliomas. Moreover, since exosomes transport chaperones and miRNAs (the latter possibly related to chaperone gene expression in the recipient cell), and probably deliver their cargo in the recipient cells, a new area of investigation is now open, which is bound to generate significant advances in the understanding and treatment of gliomas. |
| topic |
gliomas molecular chaperones Hsps (Heat shock proteins) Hsp60 miRNA exosomes extracellular vesicles theranostic tools |
| url |
http://www.mdpi.com/1422-0067/19/9/2626 |
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