Interrelationship among Obstructive Sleep Apnea, Renal Function and Survival: A Cohort Study
Previous studies showed a bidirectional relationship between renal function decline and obstructive sleep apnea (OSA) syndrome. Continuous Positive Airway Pressure (C-PAP) treatment was shown to preserve the kidney function in OSA patients. This study aims to investigate the progression of long-term...
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doaj-6e9acccbd5c84de19bb883078d3b7fff2020-11-25T03:22:08ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012020-07-01174922492210.3390/ijerph17144922Interrelationship among Obstructive Sleep Apnea, Renal Function and Survival: A Cohort StudyPatrizia Pochetti0Danila Azzolina1Beatrice Ragnoli2Paolo Amedeo Tillio3Vincenzo Cantaluppi4Mario Malerba5Respiratory Unit, Sant’ Andrea Hospital, 13100 Vercelli, ItalyDepartment of Traslational Medicine, University of Eastern Piedmont, 28100 Novara, ItalyRespiratory Unit, Sant’ Andrea Hospital, 13100 Vercelli, ItalyRespiratory Unit, Sant’ Andrea Hospital, 13100 Vercelli, ItalyDepartment of Traslational Medicine, Nephrology and Kidney Transplant Unit, University of Eastern Piedmont, 28100 Novara, ItalyRespiratory Unit, Sant’ Andrea Hospital, 13100 Vercelli, ItalyPrevious studies showed a bidirectional relationship between renal function decline and obstructive sleep apnea (OSA) syndrome. Continuous Positive Airway Pressure (C-PAP) treatment was shown to preserve the kidney function in OSA patients. This study aims to investigate the progression of long-term renal function in OSA patients treated with different PAP strategies (patients were divided into two groups, fixed C-PAP or other PAP—automatic and bilevel pressure). Comorbidities and 10-years survival were also evaluated. We performed a retrospective, observational, single-center, cohort study, including the first 40 consecutive patients enrolled from 2009 in the Respiratory disease Unit at the Vercelli University Hospital database. The patient inclusion criteria were: age ≥ 18 years with OSA syndrome according to AASM (American Academy of Sleep Medicine) guidelines. Creatinine serum levels (mg/dL) and the estimated Glomerular Filtration Rate (eGFR, mL/min calculated by CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration equation)) were measured at 3 different time points: at baseline, 3 years and 8 years after PAP treatment. The Kaplan–Meier survival curves stratified according to PAP treatment and compliance have been reported together with log-rank test estimation. In our study, we found a significant creatinine serum level reduction after 3 years of fixed C-PAP treatment (<i>p</i> value = 0.006) when compared to baseline values. However, we observed that the long-term C-PAP benefit was not significant (<i>p</i> value = 0.060). Our data confirmed the progressive renal function decline in OSA patients, especially in those using other-PAP treatments; nevertheless, OSA treatment with a fixed C-PAP device has shown, in the short term, a significant improvement in renal function. By contrast, in our study, long-term benefits after 8 years are not been demonstrated probably because of the lack of compliance of the patients and the aging effect.https://www.mdpi.com/1660-4601/17/14/4922obstructive sleep apneaC-PAPcreatinineeGFR |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Patrizia Pochetti Danila Azzolina Beatrice Ragnoli Paolo Amedeo Tillio Vincenzo Cantaluppi Mario Malerba |
spellingShingle |
Patrizia Pochetti Danila Azzolina Beatrice Ragnoli Paolo Amedeo Tillio Vincenzo Cantaluppi Mario Malerba Interrelationship among Obstructive Sleep Apnea, Renal Function and Survival: A Cohort Study International Journal of Environmental Research and Public Health obstructive sleep apnea C-PAP creatinine eGFR |
author_facet |
Patrizia Pochetti Danila Azzolina Beatrice Ragnoli Paolo Amedeo Tillio Vincenzo Cantaluppi Mario Malerba |
author_sort |
Patrizia Pochetti |
title |
Interrelationship among Obstructive Sleep Apnea, Renal Function and Survival: A Cohort Study |
title_short |
Interrelationship among Obstructive Sleep Apnea, Renal Function and Survival: A Cohort Study |
title_full |
Interrelationship among Obstructive Sleep Apnea, Renal Function and Survival: A Cohort Study |
title_fullStr |
Interrelationship among Obstructive Sleep Apnea, Renal Function and Survival: A Cohort Study |
title_full_unstemmed |
Interrelationship among Obstructive Sleep Apnea, Renal Function and Survival: A Cohort Study |
title_sort |
interrelationship among obstructive sleep apnea, renal function and survival: a cohort study |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2020-07-01 |
description |
Previous studies showed a bidirectional relationship between renal function decline and obstructive sleep apnea (OSA) syndrome. Continuous Positive Airway Pressure (C-PAP) treatment was shown to preserve the kidney function in OSA patients. This study aims to investigate the progression of long-term renal function in OSA patients treated with different PAP strategies (patients were divided into two groups, fixed C-PAP or other PAP—automatic and bilevel pressure). Comorbidities and 10-years survival were also evaluated. We performed a retrospective, observational, single-center, cohort study, including the first 40 consecutive patients enrolled from 2009 in the Respiratory disease Unit at the Vercelli University Hospital database. The patient inclusion criteria were: age ≥ 18 years with OSA syndrome according to AASM (American Academy of Sleep Medicine) guidelines. Creatinine serum levels (mg/dL) and the estimated Glomerular Filtration Rate (eGFR, mL/min calculated by CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration equation)) were measured at 3 different time points: at baseline, 3 years and 8 years after PAP treatment. The Kaplan–Meier survival curves stratified according to PAP treatment and compliance have been reported together with log-rank test estimation. In our study, we found a significant creatinine serum level reduction after 3 years of fixed C-PAP treatment (<i>p</i> value = 0.006) when compared to baseline values. However, we observed that the long-term C-PAP benefit was not significant (<i>p</i> value = 0.060). Our data confirmed the progressive renal function decline in OSA patients, especially in those using other-PAP treatments; nevertheless, OSA treatment with a fixed C-PAP device has shown, in the short term, a significant improvement in renal function. By contrast, in our study, long-term benefits after 8 years are not been demonstrated probably because of the lack of compliance of the patients and the aging effect. |
topic |
obstructive sleep apnea C-PAP creatinine eGFR |
url |
https://www.mdpi.com/1660-4601/17/14/4922 |
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