Editor’s Pick: PSMA-Specific Ligands in Prostate Cancer Diagnosis and Therapy
Prostate-specific membrane antigen (PSMA) is the most extensively studied biomarker and antigen of prostate cancer. It is overexpressed in almost all prostate cancers, and the expression level increases with prostate cancer progression. PSMA is also highly expressed in the neovasculature of solid tu...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
European Medical Journal
2016-04-01
|
Series: | European Medical Journal Urology |
Subjects: | |
Online Access: | http://emjreviews.com/wp-content/uploads/Editors-Pick-PSMA-Specific-Ligands-in-Prostate-Cancer-Diagnosis-and-Therapy.pdf |
id |
doaj-6eaa957cd2974c6a902bfb6ff58a0fa3 |
---|---|
record_format |
Article |
spelling |
doaj-6eaa957cd2974c6a902bfb6ff58a0fa32020-11-25T02:21:39ZengEuropean Medical JournalEuropean Medical Journal Urology2053-42132016-04-01416269Editor’s Pick: PSMA-Specific Ligands in Prostate Cancer Diagnosis and TherapyWei Jin0Ashutosh Barve1Kun Cheng2Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri–Kansas City, Kansas City, Missouri, USADivision of Pharmaceutical Sciences, School of Pharmacy, University of Missouri–Kansas City, Kansas City, Missouri, USADivision of Pharmaceutical Sciences, School of Pharmacy, University of Missouri–Kansas City, Kansas City, Missouri, USAProstate-specific membrane antigen (PSMA) is the most extensively studied biomarker and antigen of prostate cancer. It is overexpressed in almost all prostate cancers, and the expression level increases with prostate cancer progression. PSMA is also highly expressed in the neovasculature of solid tumours including prostate cancer. As a result, numerous PSMA-specific ligands have been discovered for prostate cancer diagnosis and therapy, and one of them has been approved for clinical use. Moreover, a number of other PSMA-specific ligands are currently evaluated in clinical studies. In this review we discuss four major types of PSMA-specific ligands, including antibody, aptamer, peptide, and small molecule inhibitor. Their emerging applications in prostate cancer diagnosis, targeted drug delivery, and therapy are also discussed.http://emjreviews.com/wp-content/uploads/Editors-Pick-PSMA-Specific-Ligands-in-Prostate-Cancer-Diagnosis-and-Therapy.pdfantibodyaptamerDiagnosispeptideProstate-specific membrane antigen (PSMA)targeted drug delivery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei Jin Ashutosh Barve Kun Cheng |
spellingShingle |
Wei Jin Ashutosh Barve Kun Cheng Editor’s Pick: PSMA-Specific Ligands in Prostate Cancer Diagnosis and Therapy European Medical Journal Urology antibody aptamer Diagnosis peptide Prostate-specific membrane antigen (PSMA) targeted drug delivery |
author_facet |
Wei Jin Ashutosh Barve Kun Cheng |
author_sort |
Wei Jin |
title |
Editor’s Pick: PSMA-Specific Ligands in Prostate Cancer Diagnosis and Therapy |
title_short |
Editor’s Pick: PSMA-Specific Ligands in Prostate Cancer Diagnosis and Therapy |
title_full |
Editor’s Pick: PSMA-Specific Ligands in Prostate Cancer Diagnosis and Therapy |
title_fullStr |
Editor’s Pick: PSMA-Specific Ligands in Prostate Cancer Diagnosis and Therapy |
title_full_unstemmed |
Editor’s Pick: PSMA-Specific Ligands in Prostate Cancer Diagnosis and Therapy |
title_sort |
editor’s pick: psma-specific ligands in prostate cancer diagnosis and therapy |
publisher |
European Medical Journal |
series |
European Medical Journal Urology |
issn |
2053-4213 |
publishDate |
2016-04-01 |
description |
Prostate-specific membrane antigen (PSMA) is the most extensively studied biomarker and antigen of prostate cancer. It is overexpressed in almost all prostate cancers, and the expression level increases with prostate cancer progression. PSMA is also highly expressed in the neovasculature of solid tumours including prostate cancer. As a result, numerous PSMA-specific ligands have been discovered for prostate cancer diagnosis and therapy, and one of them has been approved for clinical use. Moreover, a number of other PSMA-specific ligands are currently evaluated in clinical studies. In this review we discuss four major types of PSMA-specific ligands, including antibody, aptamer, peptide, and small molecule inhibitor. Their emerging applications in prostate cancer diagnosis, targeted drug delivery, and therapy are also discussed. |
topic |
antibody aptamer Diagnosis peptide Prostate-specific membrane antigen (PSMA) targeted drug delivery |
url |
http://emjreviews.com/wp-content/uploads/Editors-Pick-PSMA-Specific-Ligands-in-Prostate-Cancer-Diagnosis-and-Therapy.pdf |
work_keys_str_mv |
AT weijin editorspickpsmaspecificligandsinprostatecancerdiagnosisandtherapy AT ashutoshbarve editorspickpsmaspecificligandsinprostatecancerdiagnosisandtherapy AT kuncheng editorspickpsmaspecificligandsinprostatecancerdiagnosisandtherapy |
_version_ |
1724865162063642624 |