Early white matter development is abnormal in tuberous sclerosis complex patients who develop autism spectrum disorder

Early white matter development is abnormal in tuberous sclerosis complex patients who develop autism spectrum disorder

Abstract Background Autism spectrum disorder (ASD) is prevalent in tuberous sclerosis complex (TSC), occurring in approximately 50% of patients, and is hypothesized to be caused by disruption of neural circuits early in life. Tubers, or benign hamartomas distributed stochastically throughout the bra...

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Bibliographic Details
Main Authors: Anna K. Prohl, Benoit Scherrer, Xavier Tomas-Fernandez, Peter E. Davis, Rajna Filip-Dhima, Sanjay P. Prabhu, Jurriaan M. Peters, E. Martina Bebin, Darcy A. Krueger, Hope Northrup, Joyce Y. Wu, Mustafa Sahin, Simon K. Warfield, on behalf of the TACERN Study Group
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Autism spectrum disorder
Tuberous sclerosis complex
Infant brain development
Diffusion tensor imaging
White matter
Online Access:https://doi.org/10.1186/s11689-019-9293-x

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